Brown adipose tissue detected by PET/CT imaging is associated with less central obesity

Nuclear Medicine Communications
Aileen L GreenMedhat M Osman

Abstract

This retrospective review was performed to determine whether patients with brown adipose tissue (BAT) detected by fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) imaging have less central obesity than BMI-matched control patients without detectable BAT. Thirty-seven adult oncology patients with F-FDG BAT uptake were retrospectively identified from PET/CT studies from 2011 to 2013. The control cohort consisted of 74 adult oncology patients without detectable F-FDG BAT uptake matched for BMI/sex/season. Tissue fat content was estimated by CT density (Hounsfield units) with a subsequent noise removal step. Total fat and abdominal fat were calculated. An automated separation algorithm was utilized to determine the visceral fat and subcutaneous fat at the L4/L5 level. In addition, liver density was obtained from CT images. CT imaging was interpreted blinded to clinical information. There was no difference in total fat for the BAT cohort (34±15 l) compared with the controls (34±16 l) (P=0.96). The BAT cohort had lower abdominal fat to total fat ratio compared with the controls (0.28±0.05 vs. 0.31±0.08, respectively; P=0.01). The BAT cohort had a lower visceral fat/(visceral fat+subcutaneous fat) ratio compared wit...Continue Reading

References

Aug 29, 2002·Gastroenterology·Sherif SaadehMichael J Sheridan
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
May 10, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·K G M M AlbertiJ Shaw
Dec 15, 2006·Nature·Jean-Pierre Després, Isabelle Lemieux
Feb 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Katrine AlmindC Ronald Kahn
Jan 5, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Scott M Grundy
Jan 12, 2008·World Journal of Gastroenterology : WJG·R Scott RectorJamal A Ibdah
Apr 10, 2009·The New England Journal of Medicine·Aaron M CypessC Ronald Kahn
Apr 9, 2010·Cell Metabolism·Sven Enerbäck
Jun 2, 2010·Seminars in Nuclear Medicine·Christian Cohade
Jul 8, 2010·American Journal of Physiology. Endocrinology and Metabolism·Paul LeeMichael J Fulham
Jul 16, 2010·Diabetes Research and Clinical Practice·Gregory A Nichols, Edward J Moler
Aug 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brent A Neuschwander-Tetri
Jan 25, 2011·Nature Medicine·Alexander BarteltJoerg Heeren
Feb 8, 2011·Nature Medicine·Kevin Jon Williams, Edward A Fisher
Apr 4, 2013·Endocrine Reviews·Paul LeeKen K Y Ho
Jul 23, 2013·The Journal of Clinical Investigation·Takeshi YoneshiroMasayuki Saito
Jul 23, 2013·The Journal of Clinical Investigation·Anouk A J J van der LansWouter D van Marken Lichtenbelt
Dec 3, 2014·JACC. Cardiovascular Imaging·Ravi V ShahMatthew A Allison
Jan 8, 2015·Cell Metabolism·Aaron M CypessGerald M Kolodny
Jan 23, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard TakxAhmed Tawakol

❮ Previous
Next ❯

Citations

Aug 23, 2018·Frontiers in Endocrinology·André C CarpentierÉric E Turcotte
Sep 7, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Rita MalpiqueLourdes Ibáñez
Dec 19, 2019·Expert Opinion on Investigational Drugs·Kamran Qureshi, Brent A Neuschwander-Tetri
Aug 28, 2020·Frontiers in Endocrinology·Mingming WuDimitrios C Karampinos
Sep 13, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D FranzD C Karampinos
Dec 7, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Guillermo Sanchez-DelgadoJonatan R Ruiz
Feb 15, 2019·Frontiers in Physiology·Shireesh Srivastava, Richard L Veech
Jan 23, 2020·Reviews in Endocrine & Metabolic Disorders·Sérgio BrasilManoel J Teixeira
Jan 3, 2021·Reviews in Endocrine & Metabolic Disorders·Lissette DuarteDiego F Garcia-Diaz
Feb 20, 2021·Annals of the New York Academy of Sciences·Prasanna SanthanamRexford S Ahima
Nov 14, 2020·Cells·Miwako Nishio, Kumiko Saeki
Jun 19, 2021·The Journal of Clinical Endocrinology and Metabolism·Mya Thway TintJohan G Eriksson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
Paul LeeKen K Y Ho
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Shingo BabaRichard L Wahl
© 2022 Meta ULC. All rights reserved