PMID: 6407332Jun 1, 1983Paper

Brown adipose tissue of mice with gold thioglucose-induced obesity: effect of cold and diet

The American Journal of Physiology
S Hogan, J Himms-Hagen

Abstract

Gold thioglucose (GTG)-obese mice have a larger than normal amount of brown adipose tissue (BAT) with ultrastructurally normal mitochondria. The tissue grows normally when the mice adapt to cafeteria feeding or to cold (8 degrees C). Acute exposure to cold causes a fairly normal thermogenic activation of BAT mitochondria of GTG-obese mice, both in dynamic and static phases of their obesity. However, chow-fed GTG-obese mice have BAT mitochondria that are in a low state of thermogenic activation, and these mice fail to respond to eating a cafeteria diet for 3 wk by a normal thermogenic activation of their BAT mitochondria. More prolonged cafeteria feeding for 11-13 wk, into the static phase of obesity, is associated with thermogenic activation of BAT mitochondria of GTG-obese mice. The capacity of GTG-obese mice to respond to noradrenaline (norepinephrine) by an increase in metabolic rate is greater than that of lean mice and is further enhanced by cold acclimation. It is concluded that BAT of the GTG-obese mouse is inherently functional, as is control of its thermogenic function and growth during cold exposure and cold acclimation. Dietary influences on BAT thermogenic function are, however, defective in the GTG-obese mouse at l...Continue Reading

References

Jan 1, 1979·Nutrition and Metabolism·A DjazayeryM J Stock
Sep 6, 1979·Nature·N J Rothwell, M J Stock
Feb 22, 1978·Pflügers Archiv : European journal of physiology·P Trayhurn, W P James
May 1, 1980·The Journal of Clinical Investigation·J B Young, L Landsberg
Feb 1, 1981·Diabetologia·I De LeeuwM D'Hollander
May 1, 1982·The Journal of Clinical Investigation·J B YoungL Landsberg
Mar 1, 1981·Pflügers Archiv : European journal of physiology·N J Rothwell, M J Stock
Jul 1, 1980·The Journal of Physiology·K Brück, P Hinckel

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Citations

Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Jan 13, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vitaly RyuTimothy J Bartness

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