Brown and beige fat: From molecules to physiology and pathophysiology

Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids
Stefania CarobbioAntonio Vidal-Puig

Abstract

The adipose organ portrays adipocytes of diverse tones: white, brown and beige, each type with distinct functions. Adipocytes orchestrate their adaptation and expansion to provide storage to excess nutrients, the quick mobilisation of fuel to supply peripheral functional demands, insulation, and, in their thermogenic form, heat generation to maintain core body temperature. Thermogenic adipocytes could be targets for anti-obesity and anti-diabetic therapeutic approaches aiming to restore adipose tissue functionality and increase energy dissipation. However, for thermogenic adipose tissue to become therapeutically relevant, a better understanding of its development and origins, its progenitors and their characteristics and the composition of its niche, is essential. Also crucial is the identification of stimuli and molecules promoting its specific differentiation and activation. Here we highlight the structural/cellular differences between human and rodent brown adipose tissue and discuss how obesity and metabolic complication affects brown and beige cells as well as how they could be targeted to improve their activation and improve global metabolic homeostasis. Finally, we describe the limitations of current research models and ...Continue Reading

Citations

Aug 31, 2018·International Journal of Molecular Sciences·María Del Carmen GarcíaCarlos Diéguez
Jul 30, 2019·Advances in Nutrition·Ziye XuTizhong Shan
Feb 23, 2019·Frontiers in Physiology·Joan VillarroyaFrancesc Villarroya
Dec 12, 2018·Frontiers in Physiology·Paul Trayhurn
May 26, 2020·The Journal of Physiology·Tiina PetäistöTaina Pihlajaniemi
May 30, 2020·Lipids in Health and Disease·Katarzyna KolczynskaGrzegorz Sumara
Dec 12, 2018·Neural Regeneration Research·Aejin Lee, Ouliana Ziouzenkova
Feb 13, 2020·The Proceedings of the Nutrition Society·Paul Trayhurn
Oct 13, 2020·Frontiers in Endocrinology·Isabella Samuelson, Antonio Vidal-Puig
Nov 17, 2020·ACS Sensors·Fangxu WangNing Gu
Jul 3, 2020·Current Pharmaceutical Design·Mervin Chávez-CastilloValmore Bermúdez
Apr 23, 2021·Experimental Biology and Medicine·Yue ChenXin-Gui Peng
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Aug 23, 2021·The Journal of Nutritional Biochemistry·Sabrina FolieSusanne Kaser

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