Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice

The American Journal of Physiology
B SteflJan Kopecky

Abstract

The role of brown adipose tissue in total energy balance and cold-induced thermogenesis was studied. Mice expressing mitochondrial uncoupling protein 1 (UCP-1) from the fat-specific aP2 gene promoter (heterozygous and homozygous aP2-Ucp transgenic mice) and their nontransgenic C57BL6/J littermates were used. The transgenic animals are resistant to obesity induced by a high-fat diet, presumably due to ectopic synthesis of UCP-1 in white fat. These animals exhibited atrophy of brown adipose tissue, as indicated by smaller size of brown fat and reduction of its total UCP-1 and DNA contents. Norepinephrine-induced respiration (measured in pentobarbital sodium-anesthetized animals) was decreased proportionally to the dosage of the transgene, and the homozygous (but not heterozygous) transgenic mice exhibited a reduction in their capacity to maintain body temperature in the cold. Our results indicate that the role of brown fat in cold-induced thermogenesis cannot be substituted by increased energy expenditure in other tissues.

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Citations

Apr 18, 2020·The FEBS Journal·Mohammed Faiz HussainLawrence Kazak
May 22, 2008·American Journal of Physiology. Endocrinology and Metabolism·Vladimir KusJan Kopecky
Jul 22, 2019·International Journal of Molecular Sciences·Donghwan KimYoungsup Song
Jan 15, 2020·Molecular Biology Reports·Ayse Asiye Culum, Muhittin Yurekli
Sep 7, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M RossmeislJ Kopecký
Apr 17, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Robrecht ThoonenMarielle Scherrer-Crosbie
Oct 9, 2008·American Journal of Physiology. Endocrinology and Metabolism·Cynthia F ZizolaSilke Vogel
Sep 10, 2003·Journal of Applied Physiology·Yoriko MasudaTohru Fushiki
Nov 6, 2013·Annual Review of Physiology·Shingo Kajimura, Masayuki Saito
Nov 7, 2021·Reviews in Endocrine & Metabolic Disorders·Alexandra J BrownsteinOrian S Shirihai

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