PMID: 8603794Jan 1, 1996Paper

Brown Norway rat model of food allergy: effect of plant components on the development of oral sensitization

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
H AtkinsonK Miller

Abstract

The Brown Norway (BN) rat was examined as a model for investigating factors that influence the development of food allergy. An antigen dose-response curve for the production of antigen-specific reaginic antibody (IgE) induced through the oral route was determined. Animals were dosed orally with 1.0, 2.5, 5.0, 7.5, 10.0 and 12.0 mg ovalbumin/ml (0.5 ml/100 g twice a week for 6 wk). To promote IgE production the adjuvant carrageenan was administered once a week by the i.p. route. The effect on oral sensitization of 1.5 mg Gypsophila sp. saponin/ml administered together with the antigen on oral sensitization was examined in animals treated with 2.5, 6.0 or 10.0 mg ovalbumin/ml. The number of animals producing antigen specific reaginic antibody in response to 2.5 mg ovalbumin/ml was significantly increased (P < 0.01) in the group that received saponin with 2.5 mg ovalbumin/ml. These studies indicate that the BN rat is a sensitive model for the investigation of allergic reactions to food and has the potential to determine the impact of other dietary factors on the development of oral sensitization.

References

Jan 1, 1990·International Archives of Allergy and Applied Immunology·J SteinmannW Müller-Ruchholtz
Apr 1, 1986·European Journal of Immunology·F SuzukiR B Pollard
May 1, 1988·The American Review of Respiratory Disease·D H EidelmanJ G Martin

❮ Previous
Next ❯

Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·J C CoxI G Barr
Oct 19, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S K ClausenG D Nielsen
Apr 17, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J DearmanI Kimber
Aug 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G C Hard
Sep 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B WatzlB L Pool-Zobel
Oct 3, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L M KnippelsG F Houben
Mar 21, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R J DearmanI Kimber
Dec 31, 2002·Toxicology·Keith T Atherton
Apr 27, 2001·Toxicology Letters·I Kimber, R J Dearman
Apr 27, 2001·Toxicology Letters·A H Penninks, L M Knippels
Apr 27, 2001·Toxicology Letters·R J Dearman, I Kimber
Nov 30, 2005·The Proceedings of the Nutrition Society·Rebecca J Dearman, Ian Kimber
Feb 8, 2003·Environmental Health Perspectives·Léon M J Knippels, André H Penninks
Jun 27, 2003·Environmental Health Perspectives·Ian KimberRicki M Helm
Mar 1, 2003·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Reiko TeshimaJun-ichi Sawada
Nov 1, 1997·Environmental Toxicology and Pharmacology·C Madsen
May 30, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L M KnippelsG F Houben
Dec 14, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K MillerJ M Wal
Aug 23, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G LackUNKNOWN BSACI working party
Mar 11, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·UNKNOWN EFSA GMO Panel Working Group on Animal Feeding Trials
Nov 18, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J DearmanI Kimber
Jan 26, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F GizzarelliR Tinghino
Aug 9, 2007·Expert Opinion on Drug Delivery·Dmytro S SilinAldar S Bourinbaiar
Jan 1, 1998·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals· Elizabeth I Opara Sarah L Oehlschlager A Bryan Hanley
Oct 20, 1999·Methods : a Companion to Methods in Enzymology·L M KnippelsA H Penninks
Sep 24, 2004·Acta Veterinaria Hungarica·I Csáky, S Fekete
Apr 17, 2012·Regulatory Toxicology and Pharmacology : RTP·Sishuo CaoKunlun Huang
May 22, 2013·Journal of Allergy·Jenna L Van GrambergRobert J Bischof
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Rebecca J Dearman, Ian Kimber
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Jonathan D de JongeHenk van Loveren
Dec 13, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Toshiko OgawaHiromasa Ishii

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.