BRS1, a serine carboxypeptidase, regulates BRI1 signaling in Arabidopsis thaliana

Proceedings of the National Academy of Sciences of the United States of America
J LiJ C Walker

Abstract

Brassinosteroid-insensitive 1 (BRI1) of Arabidopsis thaliana encodes a cell surface receptor for brassinosteroids. Mutations in BRI1 severely affect plant growth and development. Activation tagging of a weak bri1 allele (bri1-5) resulted in the identification of a new locus, brs1-1D. BRS1 is predicted to encode a secreted carboxypeptidase. Whereas a brs1 loss-of-function allele has no obvious mutant phenotype, overexpression of BRS1 can suppress bri1 extracellular domain mutants. Genetic analyses showed that brassinosteroids and a functional BRI1 protein kinase domain are required for suppression. In addition, overexpressed BRS1 missense mutants, predicted to abolish BRS1 protease activity, failed to suppress bri1-5. Finally, the effects of BRS1 are selective: overexpression in either wild-type or two other receptor kinase mutants resulted in no phenotypic alterations. These results strongly suggest that BRS1 processes a protein involved in an early event in the BRI1 signaling.

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·F Dal DeganD von Wettstein
Oct 1, 1994·Trends in Biochemical Sciences·B Kobe, J Deisenhofer
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Schaller, C A Ryan
Aug 1, 1996·The Plant Journal : for Cell and Molecular Biology·P TorneroP Vera
Mar 9, 1999·The Plant Journal : for Cell and Molecular Biology·S J Clough, A F Bent
Nov 27, 1999·Science·C R SchopferJ B Nasrallah
Feb 19, 2000·Current Opinion in Plant Biology·K Schumacher, J Chory
Apr 12, 2000·Plant Physiology·D WeigelJ Chory
Dec 15, 2000·Plant Physiology·M R SussmanS Austin-Phillips
Dec 29, 2000·Nature·UNKNOWN Arabidopsis Genome Initiative

❮ Previous
Next ❯

Citations

Dec 18, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D Friedrichsen, J Chory
Apr 6, 2005·Functional & Integrative Genomics·Ying Feng, Qingzhong Xue
Nov 23, 2006·Plant Molecular Biology·Yue-Ie HsingSu-May Yu
Apr 13, 2007·Plant Molecular Biology·Michael A AyliffeAnthony J Pryor
Oct 3, 2008·Plant Molecular Biology·Shuyan WanTiegang Lu
Apr 23, 2004·Trends in Plant Science·Zhi-Yong Wang, Jun-Xian He
Mar 14, 2002·Current Opinion in Cell Biology·J Mark CockThierry Gaude
Oct 12, 2001·Trends in Endocrinology and Metabolism : TEM·C Müssig, T Altmann
Feb 8, 2002·Trends in Plant Science·Keith LindseyPaul Chilley
May 22, 2003·Trends in Plant Science·Gabrielle TichtinskyThierry Gaude
Sep 16, 2003·Current Opinion in Plant Biology·Jianming Li
May 16, 2006·Cell Research·Zhi-Yong WangChengguo Jia
Jan 13, 2009·Molecular & Cellular Proteomics : MCP·Farnusch KaschaniRenier A L van der Hoorn
Dec 14, 2002·Plant Physiology·Dong-Hoon JeongGynheung An
Feb 22, 2005·The Plant Cell·Renier A L van der HoornJonathan D G Jones
Apr 18, 2006·Biochemistry. Biokhimii︠a︡·E O FedinaI A Tarchevsky
Aug 12, 2005·Genome Génome / Conseil National De Recherches Canada·Fuzhen LiZongxiu Sun
Feb 9, 2008·Annual Review of Plant Biology·Renier A L van der Hoorn
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Philip W Becraft
Jan 1, 2002·The Arabidopsis Book·Steven D Clouse

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.