PMID: 33210589Nov 20, 2020Paper

Brucella abortus mutant strain S2308δrfbE promotes maturation and cytokine release of mouse bone marrow-derived dendritic cells

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Jingyu TanHaiwe Liu

Abstract

Objective To investigate the effect of Brucella abortus mutant strain S2308δrfbE on the maturation and immune response of mouse bone marrow-derived dendritic cells (BMDCs). Methods The expression of major histocompatibility complex I (MHC I), MHC II, CD40, CD86 were detected by flow cytometry; the secretion of cytokines tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-10 was detected by ELISA in S2308δrfbE-infected mouse BMDCs. Results The number of cells expressing MHC I, MHC II, CD40, CD86 and the secretion of cytokines TNF-α, IL-6 and IL-10 significantly increased in BMDCs infected with S2308δrfbE as compared with control groups. Conclusion S2308δrfbE promotes the maturation and enhances the inflammatory cytokines secretion in BMDCs.

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