Brugia pahangi: stage-specific antigens on microfilariae detected by serum from infected jirds or by monoclonal antibodies

Experimental Parasitology
M TomisatoY Nakajima

Abstract

Experiments were carried out to determine whether there are stage-specific antigens on microfilariae of Brugia pahangi, using sera from Mongolian jirds infected with B. pahangi and monoclonal antibodies against microfilariae of B. pahangi. These studies showed that microfilariae have both stage-specific and nonspecific antigens. The nonspecific antigens were also present on adult worms and on infective larvae. Among monoclonal antibodies, 6 out of 14 clones produced antibodies against the microfilarial stage-specific antigens, and 8 clones produced antibodies against nonspecific antigens. These monoclonal antibodies could not distinguish between adults, microfilariae, or infective larvae of B. malayi and B. pahangi.

References

Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·E C Hedge, D S Ridley
Jul 1, 1976·European Journal of Immunology·G Köhler, C Milstein
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P K Nakane, A Kawaoi

Citations

Apr 1, 1988·Experimental Parasitology·D AbrahamM Mika-Grieve
Apr 1, 1987·Experimental Parasitology·J P EhrenbergA L Scott

Related Concepts

Metazoa
Monoclonal Antibodies
Antibody Specificity
Antigenic Specificity
Antigens, Helminth
Brugia
Cross Reactions
Filarial Elephantiases
Psammomys
Peroxidase-Antiperoxidase Complex Technique

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