Brunner's gland adenoma with a focus of p53-positive atypical glands

Journal of Gastroenterology
E FujimakiY Takeda

Abstract

A submucosal tumor was resected endoscopically from the duodenal bulb in a 43-year-old man complaining of epigastric discomfort. The tumor, measuring 22 x 20 x 19mm, consisted mainly of Brunner's glands with no atypia. However, close histologic examination disclosed a focus of glands with cellular and structural atypia. The atypical glands showed staining by periodic acid-Schiff, alcian blue, and high iron-diamine methods. Mucin histochemistry was examined, and the atypical glands resembled the excretory ducts rather than the acinar cells of the tumor. Immunohistochemically, positivity for MIB-1 was high (38.0%), and p53-positive cells were detected sporadically in the atypical glands. These results indicated that the atypical glands probably represented a neoplastic lesion. Brunner's gland adenomas associated with foci of true neoplasm are very rare; only two cases, including one patient with microcarcinoid tumors, have been reported.

Citations

Jan 14, 2009·World Journal of Gastroenterology : WJG·Shoji HirasakiHisako Oshiro
Jul 28, 2012·Digestive Diseases and Sciences·Kyungeun KimEunsil Yu
Dec 2, 2011·The Journal of Small Animal Practice·E J BowenS J Baines
Apr 26, 2018·ANZ Journal of Surgery·Masayuki UrabeYasuyuki Seto
Aug 10, 2004·World Journal of Gastroenterology : WJG·Yu-Ping GaoWen-Jun Zheng
Jun 29, 2005·Histopathology·G Faller, T Kirchner
Apr 13, 2006·World Journal of Gastroenterology : WJG·Alba RoccoGerardo Nardone
Jan 1, 2016·Euroasian Journal of Hepato-gastroenterology·Aparna M PatankarPrasad Wagle
Apr 6, 2021·Open Life Sciences·Bo YangDengyang Fang
Apr 30, 2021·Advances in Therapy·Menghua ZhuXingshun Qi
Mar 1, 2006·Gastroentérologie Clinique Et Biologique·Pierre-Alexandre JustFrédérique Capron

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