BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA.

Developmental Biology
Lori Dawn Horb, Marko E Horb

Abstract

Developmental control of proliferation relies on tight regulation of protein expression. Although this has been well studied in early embryogenesis, how the cell cycle is regulated during organogenesis is not well understood. Bruno-Like RNA binding proteins bind to consensus sequences in the 3'UTR of specific mRNAs and repress protein translation, but much of this functional information is derived from studies on mainly two members, Drosophila Bruno and vertebrate BrunoL2 (CUGBP1). There are however, six vertebrate and three Drosophila Bruno family members, but less is known about these other family members, and none have been shown to function in the endoderm. We recently identified BrunoL1 as a dorsal pancreas enriched gene, and in this paper we define BrunoL1 function in Xenopus endoderm development. We find that, in contrast to other Bruno-Like proteins, BrunoL1 acts to enhance rather than repress translation. We demonstrate that BrunoL1 regulates proliferation of endoderm cells through translational control of cyclin A2 mRNA. Specifically BrunoL1 enhanced translation of cyclin A2 through binding consensus Bruno Response Elements (BREs) in its 3'UTR. We compared the ability of other Bruno-Like proteins, both vertebrate and ...Continue Reading

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Citations

Jan 26, 2016·Seminars in Cell & Developmental Biology·Julia Kofent, Francesca M Spagnoli
Dec 14, 2011·Genesis : the Journal of Genetics and Development·Cassandra K Bilogan, Marko E Horb
Dec 20, 2011·Wiley Interdisciplinary Reviews. RNA·Twishasri Dasgupta, Andrea N Ladd
Jul 21, 2012·Genesis : the Journal of Genetics and Development·Cassandra K Bilogan, Marko E Horb
Jan 19, 2012·Genesis : the Journal of Genetics and Development·Esther J PearlMarko E Horb
Nov 29, 2011·Genesis : the Journal of Genetics and Development·Daniel Oropeza, Marko Horb
Feb 15, 2011·Cell Division·Woan-Yuh Tarn, Ming-Chih Lai
Jan 19, 2013·Biochimica Et Biophysica Acta·Irina Vlasova-St LouisCarol J Wilusz
Jan 11, 2011·Developmental Biology·Esther J PearlMarko E Horb
Aug 4, 2015·Current Pathobiology Reports·Matthew C Salanga, Marko E Horb
Jun 21, 2014·Cell·Sandeepa M EswarappaPaul L Fox
Feb 23, 2012·Scientific Reports·Akio MasudaKinji Ohno
Sep 20, 2012·BMC Developmental Biology·Emily T ShifleyAaron M Zorn

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