Brushite stone disease as a consequence of lithotripsy?

Urological Research
Amy E KrambeckJames E Lingeman

Abstract

The incidence of calcium phosphate (CaP) stone disease has increased over the last three decades; specifically, brushite stones have been diagnosed and treated more frequently than in previous years. Brushite is a unique form of CaP, which in certain patients can form into large symptomatic stones. Treatment of brushite stones can be difficult since the stones are resistant to shock wave and ultrasonic lithotripsy, and often require ballistic fragmentation. Patients suffering from brushite stone disease are less likely to be rendered stone free after surgical intervention and often experience stone recurrence despite maximal medical intervention. Studies have demonstrated an association between brushite stone disease and shock wave lithotripsy (SWL) treatment. Some have theorized that many brushite stone formers started as routine calcium oxalate (CaOx) stone formers who sustained an injury to the nephron (such as SWL). The injury to the nephron leads to failure of urine acidification and eventual brushite stone formation. We explore the association between brushite stone disease and iatrogenic transformation of CaOx stone disease to brushite by reviewing the current literature.

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Citations

Oct 23, 2010·Urological Research·James C WilliamsJames E Lingeman
Jun 9, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Chengfeng LiRui Ding
Sep 1, 2015·Urolithiasis·Hans-Göran Tiselius, Christian G Chaussy
Sep 6, 2014·World Journal of Urology·Jean-Philippe Haymann
Oct 27, 2016·Journal of Nephrology·Giovanni GambaroUNKNOWN Consensus Conference Group
Jul 31, 2018·The Journal of Urology·Lael ReinstatlerVernon M Pais
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Mar 9, 2018·Advances in Urology·Tilahun Alelign, Beyene Petros
Mar 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mazeyar Parvinzadeh GashtiJürg Hulliger

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