Brysocarpus coccineus (Schum & Thonn) root reinstates sexual competence and testicular function in paroxetine-induced sexual dysfunction in male Wistar rats

Andrologia
Musa T Yakubu, A R Atoyebi

Abstract

The effects of aqueous extract of Brysocarpus coccineus roots (AEBCR) were studied on sexual behaviour and testicular function of paroxetine-induced sexual dysfunction (SD) in male rats. Ninety, sexually matured male rats (150.88 ± 5.53 g) were assigned into two groups: A and B. Fifteen SD animals from group B were each allotted to B1, B2, B3, B4 and B5 and received distilled water (DW), Powmax M (7.14 mg/kg body weight, b.w.) 50, 100 and 150 mg/kg b.w of AEBCR, respectively, for 7 days while the non-SD animals (group A) received DW. Eleven secondary metabolites were present in AEBCR. The lowered (p < .05) ejaculation frequency, penile erection index and penile grooming, higher mount and intromission frequencies, prolonged (p < .05) latencies of mount, intromission, ejaculation, and post-ejaculatory interval, reduced (p < .05) serum luteinising hormone, follicle stimulating hormone, testosterone, nitric oxide and testicular function indices, degenerated seminiferous tubules and low luminal spermatozoa contents by paroxetine were significantly (p < .05) attenuated and/or reinstated by AEBCR and Powmax M. The restoration of androgen-dependent sexual and testicular functions in SD male rats by AEBCR validates its folkloric use as ...Continue Reading

References

May 1, 1991·Journal of Ethnopharmacology·M W IslamA M al-Yhya
Feb 1, 1986·Biology of Reproduction·M L Meistrich
Mar 28, 1973·Journal of Chromatography·E Ragazzi, G Veronese
Jan 19, 1967·The New England Journal of Medicine·D S FredricksonR S Lees
May 1, 1997·Brain Research. Brain Research Protocols·A Agmo
Apr 1, 1954·The Biochemical Journal·A KEMP, A J M K VAN HEIJNINGEN
Oct 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·F WROBLEWSKI, J S LADUE
Nov 15, 2003·Psychopharmacology·Augusta BenelliSusanna Genedani
May 26, 2004·Pharmacology, Biochemistry, and Behavior·M Carro-JuárezG Rodríguez-Manzo
Jun 24, 2004·Primary Care Companion to the Journal of Clinical Psychiatry·Paul A. PirragliaDaniel E. Singer
Dec 15, 2005·International Journal of Clinical Practice·J L Carrasco, C Sandner
Apr 25, 2006·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Sidney H KennedyShahryar Rafi-Tari
May 2, 2006·Acta Biologica Hungarica·W D Ratnasooriya, J R A C Jayakody
Jun 6, 2006·Journal of Ethnopharmacology·A J Akindele, O O Adeyemi
Oct 19, 2006·World Journal of Urology·Stefan UckertChristian G Stief
Nov 23, 2006·Fitoterapia·A J Akindele, O O Adeyemi
Dec 16, 2006·The Journal of Clinical Hypertension·Arthur L Burnett
Sep 16, 2009·The Journal of Sexual Medicine·Xiaoying WangJuntian Zhang
Mar 12, 2010·Journal of Ethnopharmacology·Abidemi J AkindeleOlufunmilayo O Adeyemi
Oct 20, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Peter J O'Shaughnessy, Paul A Fowler
Nov 10, 2010·Reproductive Biology and Endocrinology : RB&E·Águeda OrtizAna B Rodríguez
Jan 22, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·M T Yakubu, M A Akanji
Jun 26, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Da WoHui-ming Mao
Jul 3, 2013·Physiology·George F LaskerPhilip J Kadowitz
Dec 5, 2013·Experimental Biology and Medicine·Mohammed Z AllouhAyman G Mustafa
Dec 20, 2013·Journal of Basic and Clinical Physiology and Pharmacology·Taofeek O AjiboyeMusa T Yakubu
Jan 2, 2014·Spermatogenesis·Kar Wah Leung, Alice St Wong
Mar 20, 2014·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Fikret ErdemirErkan Sogut
May 31, 2014·Biochimica Et Biophysica Acta·Aki MurashimaGen Yamada

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.