BSE immunohistochemical patterns in the brainstem: a comparison between UK and Italian cases

Acta Neuropathologica
Cristina CasaloneMarion Simmons

Abstract

The continuous monitoring of bovine spongiform encephalopathy (BSE) cases is an integral component of European research and surveillance programmes, to ensure that any changes in the presentation of transmissible spongiform encephalopathies (TSE) in cattle can be detected and defined. Monitoring is generally limited to the brainstem at the level of the obex, for reasons of practicality, safety and cost. Demonstration of disease-specific prion protein (PrP(d)) by immunohistochemistry is currently the most widely used confirmatory tool for both active and passive surveillance. This study assessed PrP(d) immunostaining in the brainstems (obex) of cattle with BSE in the UK and Italy. Immunoreactivity 'profiles' were created for each case based on the nature of the immunostaining, its relative intensity and precise neuroanatomical location. This study compares the obex immunostaining patterns of Italian cases (only active surveillance) and two UK groups (both active and passive surveillance). The neuroanatomical distribution and relative intensity of PrP(d) was highly reproducible in all cases. The overall staining intensity varied widely but was generally stronger in the active than in the passive surveillance populations. The conc...Continue Reading

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Feb 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Cristina CasaloneMaria Caramelli

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Citations

Sep 27, 2007·Archives of Virology·M P PolakJ P M Langeveld
Feb 15, 2007·BMC Veterinary Research·Timm KonoldMarion M Simmons
Mar 1, 2007·Emerging Infectious Diseases·Torsten SeuberlichAndreas Zurbriggen
Dec 23, 2008·Research in Veterinary Science·Shozo AraiSadao Onoe
Jun 6, 2009·Zoonoses and Public Health·M StackL Terry
Oct 15, 2014·Neuropathology and Applied Neurobiology·Ilaria MirabileJohn Collinge
Jan 10, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Dolores Gavier-WidénThierry G M Baron
Sep 13, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Amir N HamirRandall C Cutlip
Nov 23, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Torsten SeuberlichAndreas Zurbriggen
Aug 11, 2017·Transboundary and Emerging Diseases·M SimmonsT Seuberlich
Dec 20, 2012·The Veterinary Record·M J StackP Burke

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