BsmI polymorphism in the vitamin D receptor gene is associated with leg extensor muscle strength in elderly men

Aging Clinical and Experimental Research
Gulistan BahatMehmet Akif Karan

Abstract

Sarcopenia is defined as a reduction in skeletal muscle mass, strength, and endurance observed with advancing age. Although Vitamin D receptor (VDR) polymorphism is reported to be associated with muscle mass and strength, evidence for this is limited and conflicting. In this study, we examined the association between the polymorphisms of VDR gene BsmI, TaqI and FokI and muscular mass and strength in elderly men. This is a cross-sectional study conducted in a university hospital. One hundred and twenty men over 65 years of age participated, all participants were active men living independently in Istanbul, who were followed as outpatients in geriatric polyclinics. Most common diagnoses were hypertension, hyperlipidemia, and mild to moderate osteoarthritis. Morbid obese patients were not included in the study. Genomic DNA was extracted from peripheral blood, and VDR genotypes were determined by the polymerase chain reaction. The peak torque of the knee flexors and extensors was measured on a Cybex 350 dynamometer. Body muscle mass was calculated by using bioelectric impedance analysis. The extensor strength of the knee was higher in BB homozygotic men than in the Bb/bb group. No significant association was found with TaqI and Fok...Continue Reading

References

Apr 1, 1985·The American Journal of Clinical Nutrition·H C LukaskiG I Lykken
Jan 8, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GeusensJ Raus
Apr 29, 1998·American Journal of Epidemiology·R N BaumgartnerR D Lindeman
Apr 2, 1999·Biochimica Et Biophysica Acta·L K DurrinG A Coetzee
May 2, 2000·Archives of Internal Medicine·A PrabhalaP Dandona
Dec 29, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R Roubenoff, V A Hughes
May 30, 2001·Molecular and Cellular Endocrinology·G K WhitfieldM R Haussler
Mar 29, 2003·Mechanisms of Ageing and Development·L J S Greenlund, K S Nair
Sep 26, 2003·American Journal of Preventive Medicine·Edward M CastilloElizabeth Barrett-Connor
Oct 23, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Taylor J Marcell
Dec 23, 2003·Journal of the American Geriatrics Society·Ian JanssenRonenn Roubenoff
Jan 14, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stephen M RothRobert E Ferrell
Aug 19, 2004·Gene·André G UitterlindenJohannes P T M Van Leeuwen
Apr 5, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A WindelinckxM A I Thomis
Feb 28, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Graziano OnderFrancesco Landi

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Citations

Sep 13, 2012·Calcified Tissue International·Lisa Ceglia, Susan S Harris
Nov 1, 2011·Age·Nuria Garatachea, Alejandro Lucía
Jul 15, 2015·Experimental and Therapeutic Medicine·Myosotis MassiddaCarla M Calò
Apr 19, 2013·Revista española de cirugía ortopédica y traumatología·M Mesa-RamosP Carpintero-Benítez
Sep 30, 2015·Aging Clinical and Experimental Research·Sean WalshStephen M Roth
Jan 19, 2016·Current Nutrition Reports·Denise K Houston
Oct 2, 2012·Ageing Research Reviews·Nuria Garatachea, Alejandro Lucia
Mar 5, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Arpad BozsodiAron Lazary
Dec 22, 2019·Cells·Jedd PrattGiuseppe De Vito
Feb 11, 2014·Exercise and Sport Sciences Reviews·Rachele M Pojednic, Lisa Ceglia
Nov 22, 2012·Endocrine Reviews·Christian M GirgisJenny E Gunton
Sep 20, 2011·Sports Medicine·Zudin PuthuchearyHugh E Montgomery
Mar 1, 2012·Asian Journal of Sports Medicine·Bruce Hamilton
Jul 20, 2010·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Gulistan BahatMehmet A Karan
Feb 15, 2019·International Journal of Environmental Research and Public Health·Melissa DangDavid Scott
Jan 29, 2021·Frontiers in Genetics·Felicita UrziElena Buzan

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