BST2 promotes cell proliferation, migration and induces NF-κB activation in gastric cancer

Biotechnology Letters
Weiyu LiuChangqing Zheng

Abstract

To investigate the functional roles of bone marrow stromal cell antigen 2 (BST2) in gastric cancer (GC) cells and its implications in the development of GC patients. BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demonstrated that knockdown of BST2 by siRNA inhibited cell proliferation, induced apoptosis and repressed cell motility in GC cells. In addition, the pro-tumor function of BST2 in GC was mediated partly through the NF-κB signaling. BST2 possesses the oncogenic potential in GC by regulating the proliferation, apoptosis, and migratory ability of GC cells, thereby BST2 could be a potential therapeutic target for the treatment of GC.

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Citations

Apr 14, 2019·International Journal of Clinical Oncology·Naohide OueWataru Yasui
Jun 25, 2020·Proceedings of the National Academy of Sciences of the United States of America·Leah McNallySusan J Fisher
Nov 6, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ayaha YamamotoMasanori Obana
Apr 4, 2021·International Journal of Molecular Sciences·Lornella SeeneevassenChristine Varon

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Datasets Mentioned

BETA
GES-1

Methods Mentioned

BETA
PCR
flow cytometry
transfection
nuclear translocation

Software Mentioned

GraphPad Prism
- Pro Analyzer
Gel

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