BT-11 improves stress-induced memory impairments through increment of glucose utilization and total neural cell adhesion molecule levels in rat brains

Journal of Neuroscience Research
Ki Young ShinYoo-Hun Suh

Abstract

In Oriental medicine, roots of Polygala tenuifolia Willdenow have been known to be an important herb that exhibits sedative effects in insomnia, palpitation with anxiety, restlessness, and disorientation in humans. We previously reported that BT-11, extracted from those roots, improved scopolamine-induced amnesia in rats and inhibited acetylcholinesterase activities in vitro. Therefore, we proposed that BT-11 could remedy stress-induced memory deficits in rats. In this study, the stress-induced memory impairments in rats were significantly reversed almost to the control level by BT-11 treatment. To seek an active component of BT-11 that plays an important role in antipsychotic effects, we compared BT-11 with 3,4,5-trimethoxycinnamic acid (TMCA), which is a constituent of those root extracts. However, the effects of TMCA were less or were not consistent with those of BT-11 in some of tests. In particular, BT-11 reversed the stress-induced reduction of glucose utilization by [(18)fluorodeoxyglucose]FDG-PET and the levels of neural cell adhesion molecule (NCAM) in rat brains to the control levels, whereas TMCA did not. Therefore, BT-11 improved stress-induced memory impairments through increment of glucose utilization and total NC...Continue Reading

References

Jan 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H T ChuganiW F Xu
May 1, 1982·Archives of General Psychiatry·R M CohenD L Murphy
Mar 1, 1995·Neurobiology of Aging·M HatzingerI J Heuser
Jan 1, 1997·Molecular and Cellular Neurosciences·H CremerA Represa
Oct 23, 1997·Current Opinion in Cell Biology·M Schachner
Jun 10, 1998·Psychoneuroendocrinology·J W NewcomerG Vogler
Jun 8, 1999·Archives of General Psychiatry·J W NewcomerA L Alderson
Nov 3, 2001·Brain Research. Brain Research Reviews·J Z KissD Muller
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·In-Won ChungYong Sik Kim
Oct 23, 2002·Journal of Neuroscience Research·Cheol Hyoung ParkYoo-Hun Suh
Feb 1, 2003·Neurobiology of Learning and Memory·Benno Roozendaal
Jun 26, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ja Wook KooYoo-Hun Suh
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Kazushige MizoguchiTakeshi Tabira
Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Zahoor Ahmad ShahS B Vohora
Jul 17, 2004·Biological & Pharmaceutical Bulletin·Yukinobu IkeyaMasaki Aburada
Aug 12, 2004·Biological & Pharmaceutical Bulletin·Keiko KawashimaYoshihiro Kano
Nov 20, 2004·Nature Reviews. Neuroscience·Carmen Sandi
Jul 20, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Patrícia PereiraPatrícia Ardenghi
Nov 23, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Borja García-BuenoJuan C Leza
Jan 25, 2007·Psychosomatic Medicine·Robert S WilsonDavid A Bennett
Apr 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael TsooryGal Richter-Levin
May 10, 2007·Canadian Journal of Physiology and Pharmacology·Silvana Soriano FrassettoAnapaula Sommer Vinagre

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Citations

Mar 23, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Shu Ping XuPengtao Li
Aug 3, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Zhihong LinJyoti Kumar Tiwari
Jun 7, 2011·Drugs & Aging·Melanie-Jayne R Howes, Elaine Perry
Nov 30, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hemant KumarDong-Kug Choi
Jul 9, 2010·European Journal of Pharmacology·Yu-Jing ChenLin Li
May 29, 2013·CNS Neuroscience & Therapeutics·Jin-Xia ZhouXiao-Min Wang
Nov 29, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Ki Young ShinHyung Gun Lee
May 4, 2011·Neuroscience Letters·Zhigang LiangXiaomin Wang
Jan 5, 2011·Journal of Ethnopharmacology·Jin Gyu ChoiMyung Sook Oh
Feb 11, 2015·Regulatory Toxicology and Pharmacology : RTP·Ki Young ShinHyung Gun Lee
May 22, 2013·Physiology & Behavior·Zhao-Lin CaiChu-Hua Li
Mar 19, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hee Jin KimYoo-Hun Suh
Sep 5, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hemant KumarDong-Kug Choi
Feb 22, 2012·Chemistry & Biodiversity·Luiz Carlos KleinValdir Cechinel Filho
Sep 24, 2011·Stress : the International Journal on the Biology of Stress·Reto Bisaz, Carmen Sandi

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