Bu-Shen-Yi-Qi formula ameliorates airway remodeling in murine chronic asthma by modulating airway inflammation and oxidative stress in the lung

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Jie CuiJingcheng Dong

Abstract

Bu-Shen-Yi-Qi formula (BSYQF) could suppress chronic airway inflammation according to previous studies. However, there is relatively little direct experimental evidence to evaluate the effects of BSYQF treatment on airway remodeling in chronic asthma. Recent evidence suggests that oxidative stress is involved in airway inflammation and airway remodeling in chronic asthma. BSYQF which includes various of chemical components having antioxidant effects, could be beneficial in attenuating airway remodeling in chronic asthma. The purpose of this study was to elucidate the effect of BSYQF treatment on airway remodeling and investigate its potential mechanisms in chronic asthma. To develop the murine models of chronic asthma, BALB/c mice were sensitized and challenged to ovalbumin for 8 weeks. BSYQF (5, 10, 20 g raw herbs/kg body weight) or tiotropium bromide (0.1 mM) were administered orally and intranasal instillation, respectively. The effect of BSYQF on pulmonary inflammation and remodeling was evaluated. The parameters of oxidative stress in the lung were analyzed. BSYQF treatment reduced airway hyperresponsiveness (AHR), Th2 response including IL-4, IL-13, and OVA-specific IgE and IgG1, transforming growth factor-β (TGF-β), vasc...Continue Reading

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Citations

Nov 30, 2019·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Yiping LinYunguang Wang
Nov 18, 2020·BMC Pulmonary Medicine·Da-Wei ZhangGuang-He Fei
Nov 14, 2020·Journal of Ethnopharmacology·Jun-Xi LiuJun Liang
Nov 10, 2020·Journal of Reproductive Immunology·Che Ismail WafriyMohammad Hanafiah
Jun 1, 2021·Bioscience, Biotechnology, and Biochemistry·Qiang LiZhanli Shi

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