Bu4 NI-catalyzed, oxidative C(sp2 ) -C(sp3 ) cross dehydrogenative coupling for the regioselective direct C-3 benzylation of 2H-indazoles

Organic & Biomolecular Chemistry
Lalit Yadav, Sandeep Chaudhary

Abstract

A Bu4NI-catalyzed, DTBP-promoted, regioselective C(sp2)-C(sp3) cross dehydrogenative coupling (CDC) protocol for the direct C-3 benzylation of 2H-indazoles is reported. The metal-free protocol is operationally simple and proceeds mechanistically via the generation of stable benzylic free-radicals followed by regioselective addition at the C-3 position of 2H-indazoles which afforded C-3 benzylated 2H-indazoles up to 87% yields. The methodology showed a varied array of functional group tolerance and wide substrate compatibility. The gram-scale synthesis further highlights the importance and versatile nature of this methodology.

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Citations

Nov 6, 2020·Chemical Communications : Chem Comm·Guo-Qing JinHua-Yue Wu
Feb 9, 2021·Organic & Biomolecular Chemistry·Kai WangYuanyuan Xie

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Methods Mentioned

BETA
column chromatography

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