PMID: 25731627Mar 4, 2015Paper

Buccal cell cytokeratin 14 identifies mild cognitive impairment and Alzheimer' s disease in the AIBL study of aging

Current Alzheimer Research
Wayne R LeifertMichael F Fenech

Abstract

Previous studies have suggested that mild cognitive impairment (MCI) may be reflective of the early stages of neurodegenerative disorders such as Alzheimer's disease (AD). The hypothesis was that cytokeratin (CK) 14 expression can be used as a biomarker in isolated buccal mucosa to identify individuals with MCI or AD from the Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging. Visual assessment of buccal cell CK14 expression was carried out using immunofluorescence techniques. The frequency of basal buccal cells expressing CK14 was significantly lower in the MCI (P=0.0002) and AD (P<0.05) groups compared with the control group. Receiver-operating characteristic (ROC) curves were carried out for CK14 expression and yielded an area under the curve (AUC) of 0.899 for the MCI (P<0.0001) group and 0.772 for the AD (P=0.004) group. When the CK14 expression data were combined with plasma homocysteine concentration, the AUC was further improved to 0.932 and 0.788 for the MCI (P=0.0001) and AD (P=0.004) groups, respectively. APOE ε4 carriers in the control group had 21% lower CK14 expression compared with control non APOE ε4 carriers, however this difference was not statistically significant. The changes in the ...Continue Reading

Citations

Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Wayne R LeifertUNKNOWN Australian Imaging, Biomarkers and Lifestyle Study Research Group
Oct 23, 2018·Current Alzheimer Research·Maxime FrançoisWayne R Leifert
Dec 30, 2017·Molecular Medicine Reports·Yue Deng, Weiyuan Ma
Dec 30, 2017·Oncology Letters·Hani ChoudhryMahmoud Alhosin
Feb 19, 2021·Neurodegenerative Disease Management·Felix Menne, Carola G Schipke

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