Buckwheat and CVD Risk Markers: A Systematic Review and Meta-Analysis

Nutrients
Liangkui LiChris Seal

Abstract

The effects of buckwheat intake on cardiovascular diseases (CVDs) have not been systematically investigated. The aim of the present study was to comprehensively summarize studies in humans and animals, evaluating the impact of buckwheat consumption on CVD risk markers and to conduct a meta-analysis of relevant data. Thirteen randomized, controlled human studies, two cross-sectional human studies and twenty-one animal studies were identified. Using random-effects models, the weighted mean difference of post-intervention concentrations of blood glucose, total cholesterol and triglycerides were significantly decreased following buckwheat intervention compared with controls [differences in blood glucose: -0.85 mmol/L (95% CI: -1.31, -0.39), total cholesterol: 0.50 mmol/L (95% CI: -0.80, -0.20) and triglycerides: 0.25 mmol/L (95% CI: -0.49, -0.02)]. Responses of a similar magnitude were seen in two cross-sectional studies. For animal studies, nineteen of twenty-one studies showed a significant reduction in total cholesterol of between 12% and 54%, and fourteen of twenty studies showed a significant reduction in triglycerides of between 2% and 74%. All exhibited high unexplained heterogeneity. There was inconsistency in HDL cholester...Continue Reading

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Citations

Nov 17, 2020·Critical Reviews in Food Science and Nutrition·Aysegul Ugural, Aslı Akyol
Sep 20, 2020·Food Chemistry·Peter Francis RaguindinHua Kern
Jul 20, 2021·Critical Reviews in Food Science and Nutrition·Liang ZouJianbo Xiao
May 19, 2020·Cardiovascular & Hematological Agents in Medicinal Chemistry·Sibu P SahaThomas F Whayne

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