Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils.

Nature Communications
Yang SongHo Cheung Shum

Abstract

Networks of natural protein nanofibrils, such as cytoskeletal filaments, control the shape and the division of cells, yet mimicking this functionality in a synthetic setting has proved challenging. Here, we demonstrate that artificial networks of protein nanofibrils can induce controlled deformation and division of all-aqueous emulsion droplets with budding-like morphologies. We show that this process is driven by the difference in the immersional wetting energy of the nanofibril network, and that both the size and the number of the daughter droplets formed during division can be controlled by modulating the fibril concentration and the chemical properties of the fibril network. Our results demonstrate a route for achieving biomimetic division with synthetic self-assembling fibrils and offer an engineered approach to regulate the morphology of protein gels.

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Citations

Nov 6, 2018·Organic & Biomolecular Chemistry·Richard BoothJavier Montenegro
Mar 5, 2019·Advanced Materials·Joe ForthThomas P Russell
Jul 5, 2019·Advanced Materials·Xiaoxuan ZhangYuanjin Zhao
May 1, 2019·Chembiochem : a European Journal of Chemical Biology·Nicolas Martin
Nov 22, 2019·Chemical Society Reviews·Youchuang Chao, Ho Cheung Shum
Dec 15, 2018·Small·Zhou LiuTiantian Kong
Jan 11, 2020·Research : a Science Partner Journal·Changmin ShaoYuanjin Zhao
Apr 16, 2020·Advanced Biosystems·Jie WangYuanjin Zhao
Nov 8, 2019·Physical Review Letters·Hau Yung LoLei Xu
Feb 19, 2019·Frontiers in Chemistry·Hiroki SakutaKenichi Yoshikawa
Feb 20, 2020·Proceedings of the National Academy of Sciences of the United States of America·Lingyu SunYuanjin Zhao
Mar 14, 2020·Nature Communications·Stefan RobertsAshutosh Chilkoti
Mar 8, 2020·Biophysics Reviews·Kanta TsumotoKenichi Yoshikawa
Nov 17, 2020·Biomicrofluidics·Mao-Jie ZhangLiang-Yin Chu
Mar 25, 2021·ACS Nano·Yi ShenTuomas P J Knowles
Jul 17, 2021·Global Challenges·Pantelitsa DimitriouDavid Barrow
Jan 17, 2019·ACS Applied Materials & Interfaces·Kaixuan ZhuYuanjin Zhao
Sep 29, 2018·ACS Applied Materials & Interfaces·Xiangyu FuHo Cheung Shum
Jul 13, 2019·ACS Nano·Ahanjit Bhattacharya, Neal K Devaraj
Nov 25, 2020·ACS Applied Materials & Interfaces·Dandan LinThomas P Russell
Oct 1, 2021·Nature Communications·Yan ZhangMark P Styczynski

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Methods Mentioned

BETA
fluorescence microscopy
scanning electron microscopy

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