PMID: 8601317Mar 22, 1996Paper

Budding of rabies virus particles in the absence of the spike glycoprotein

Cell
T MebatsionKarl-Klaus Conzelmann

Abstract

Budding of enveloped viruses from cellular membranes is believed to de pend on the presence of transmembrane spike proteins interacting with cytoplasmic virus components. To address the mechanism of rhabdovirus budding, we generated rabies virus mutants deficient for the glycoprotein G or the G cytoplasmic tail. We found that spikeless rhabdovirus particles were released from cells infected with the G-deficient mutant, demonstrating that a viral surface protein is not required to drive the budding process. However, particle production is enhanced approximately 6-fold and 30-fold in the presence of tailless G or G, respectively. This reveals that G also possesses an intrinsic and independent exocytosis activity. We propose a model according to which efficient budding of rhabdoviruses is achieved by a concerted action of both core and spike proteins.

References

Sep 1, 1991·Virology·Y GaudinA Flamand
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·V Bruss, D Ganem
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T R FuerstB Moss
Nov 19, 1981·Nature·A AnilionisP J Curtis
Nov 1, 1982·The Journal of General Virology·J Závada
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·S P WhelanG T Wertz
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·N D LawsonJ K Rose
Feb 24, 2001·Journal of Medical Microbiology·M T Parker

❮ Previous
Next ❯

Citations

Apr 1, 1997·Reviews in Medical Virology·F Radecke, M A Billeter
Oct 1, 1996·Trends in Microbiology·K K Conzelmann, G Meyers
May 12, 2005·Virus Research·Stefan Finke, Karl-Klaus Conzelmann
May 12, 2001·Vaccine·K MorimotoM J Schnell
Mar 22, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ding-Gang YangYu-Chen Hu
Jul 13, 2012·Nature·Byung Kook LimRobert C Malenka
Oct 16, 2012·Nature·Stephan LammelRobert C Malenka
Dec 21, 2006·Nature Methods·Ian R WickershamEdward M Callaway
Jul 28, 2013·Nature Protocols·Fumitaka Osakada, Edward M Callaway
Dec 1, 2009·Nature Reviews. Microbiology·Matthias J SchnellAmy Papaneri
Nov 1, 2000·Molecular Plant Pathology·K I PosthumaY Hong
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·H D FoleyM J Schnell
Aug 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kevin T BeierConstance L Cepko
Oct 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mar PerezJuan C de la Torre
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·T MebatsionK K Conzelmann
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·P PaleseA García-Sastre
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·M J SchnellJ K Rose
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·T Mebatsion, K K Conzelmann
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·P C Roberts, R W Compans
Dec 1, 1996·The Journal of Cell Biology·M SuomalainenH Garoff
May 29, 2002·Hybridoma and Hybridomics·Bernhard Dietzschold, Matthias J Schnell
Apr 9, 2008·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·René AssenbergJonathan M Grimes
Sep 7, 2006·Journal of Clinical Microbiology·T NagarajanV A Srinivasan
Apr 27, 2007·Journal of Virology·Milosz FaberBernhard Dietzschold
Nov 12, 2010·Journal of Virology·Christoph Wirblich, Matthias J Schnell
Oct 12, 2007·Journal of Virology·Yvonne KlingenStefan Finke
Jan 8, 2010·Journal of Virology·Emily A GommeMatthias J Schnell
Oct 31, 2008·Journal of Virology·Christopher W BrownBrian D Lichty
Nov 23, 2000·Journal of Virology·P Gómez-PuertasA Portela

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.