Budesonide, a locally acting steroid, prevents graft rejection in a rat model of intestinal transplantation

Transplantation
N OzcayR Zhong

Abstract

The requirement for potent systemic immunosuppression to prevent intestinal graft rejection has resulted in high rates of infection and post-transplant lymphoproliferative disease. Budesonide (BUD) is a locally acting steroid that is almost completely metabolized during its first pass through the intestinal wall and liver. The present study examined whether BUD could prevent small bowel allograft rejection without causing the adverse systemic effects associated with prednisolone. Orthotopic Brown Norway to Lewis rat small bowel allotransplants were randomly assigned to treatment with low-dose BUD (0.1 mg/kg/day, p.o.) and high-dose BUD (1.0 mg/kg/day, p.o.) with and without cyclosporine (CsA; 2 mg/kg/day s.c.). The following parameters were assessed: allograft survival, recipient plasma adrenocorticotrophic hormone (ACTH) levels, recipient adrenal, splenic and thymic weights, recipient CsA levels, and graft histopathology. Low- and high-dose BUD alone did not prolong graft survival compared with the untreated group (9.1+/-0.4 days vs. 11+/-0.8 days vs. 9.7+/-0.4 days, respectively). However, when low-dose BUD and high-dose BUD were given in combination with CsA, the mean graft survival times were prolonged to 27.6+/-5.3 and 36....Continue Reading

References

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Citations

Sep 4, 2009·The New England Journal of Medicine·Thomas M Fishbein
Apr 15, 2014·Transplant Immunology·Fredrik Åberg
Feb 14, 2008·Digestive Diseases and Sciences·Aducio L ThiesenAlan B Thomson
Oct 19, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mamatha BhatMarc Deschenes
Aug 14, 2002·World Journal of Gastroenterology : WJG·Xiao-Ting WuXie-Lin Feng
Oct 23, 2002·Journal of Applied Physiology·Aducio L ThiesenAlan B Thomson
Jul 1, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Khurram BariKenneth E Sherman

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