Budesonide and mesalazine in active Crohn's disease: a comparison of the effects on quality of life

The American Journal of Gastroenterology
Ole O ThomsenInternational Budesonide-Mesalazine Study Group

Abstract

Controlled ileal release budesonide and slow release mesalazine are both used to treat mild to moderate active Crohn's disease, although data show that budesonide is more effective in inducing remission. When comparing different treatment options, the effects of agents on health-related quality of life must be considered as well as efficacy. In this study, we sought to compare the effects of budesonide and mesalazine on the health-related quality of life of patients with active Crohn's disease. The study included 182 patients with Crohn's Disease Activity Index scores between 200 and 400. Patients were randomized in a double blind, double dummy, multicenter study to receive 9 mg of budesonide, once daily (n = 93), or 2 g of mesalazine, b.i.d. (n = 89), for 16 wk. Quality of life was assessed at baseline and after 2, 4, 8, 12, and 16 wk of treatment using the Psychological General Well-Being index. In addition, a physician's global evaluation was used to assess how symptoms affected patients' normal activities. Patients treated with budesonide experienced significantly greater improvement in Psychological General Well-Being scores than the group treated with mesalazine after 2, 8, 12, and 16 wk. All components of this index show...Continue Reading

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Citations

Dec 9, 2010·Arquivos De Gastroenterologia·UNKNOWN Brazilian Study Group of Inflammatory Bowel Diseases
Jul 4, 2016·The Cochrane Database of Systematic Reviews·Wee-Chian LimStephen Hanauer
Feb 22, 2002·The Medical Letter on Drugs and Therapeutics
Jun 4, 2015·The Cochrane Database of Systematic Reviews·Ali RezaieCynthia H Seow
Jul 13, 2012·Journal of Crohn's & Colitis·Tiago NunesMiquel Sans

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