Budesonide/formoterol: a review of its use in asthma

Drugs
David R Goldsmith, Gillian M Keating

Abstract

Budesonide and formoterol have been combined in a single dry powder device, Symbicort Turbuhaler (budesonide/formoterol 160/9-640/18 microg/day), in an effort to simplify asthma management. The efficacy of budesonide/formoterol as maintenance therapy in patients with asthma has been examined in several randomised studies.Twice-daily budesonide/formoterol was significantly more effective than an equivalent or higher daily dose of budesonide alone or high-dose fluticasone propionate alone at improving peak expiratory flow (PEF) in adults with predominantly moderate persistent asthma. Symptom control and the risk of mild exacerbations were significantly improved versus budesonide alone. Moreover, budesonide/formoterol appeared to be as effective as concurrent therapy with equivalent dosages of budesonide and formoterol administered via separate inhalers in adults with moderate persistent asthma. Budesonide/formoterol administered once daily was as effective as twice-daily administration (equivalent daily doses) and more effective than once-daily budesonide in adults with moderate persistent asthma. Twice-daily budesonide/formoterol significantly improved PEF compared with budesonide in paediatric patients with asthma. Adjustable m...Continue Reading

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Citations

Jan 11, 2005·American Journal of Respiratory and Critical Care Medicine·Peter J Barnes
Apr 1, 2008·Expert Review of Respiratory Medicine·Pierluigi PaggiaroAlberto Papi
Mar 11, 2015·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Satu LähelmäMerja Kirjavainen
Jan 23, 2016·Expert Opinion on Pharmacotherapy·Hiroshi Chantaphakul, Kiat Ruxrungtham
Jun 10, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·William E Berger, Michael J Noonan
May 4, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Yasushi ObaseMikio Oka
Jan 22, 2010·Expert Opinion on Pharmacotherapy·Pierachille SantusStefano Centanni
Oct 7, 2010·Expert Review of Respiratory Medicine·David HodgsonTim Harrison
Dec 19, 2015·Expert Review of Respiratory Medicine·Todor A PopovFrancis Vanderbist
Aug 31, 2019·Drugs·Zaina T Al-Salama, James E Frampton

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