Buffer mobility and the regulation of neuronal calcium domains

Frontiers in Cellular Neuroscience
Elizabeth A Matthews, Dirk Dietrich

Abstract

The diffusion of calcium inside neurons is determined in part by the intracellular calcium binding species that rapidly bind to free calcium ions upon entry. It has long been known that some portion of a neuron's intracellular calcium binding capacity must be fixed or poorly mobile, as calcium diffusion is strongly slowed in the intracellular environment relative to diffusion in cytosolic extract. The working assumption was that these immobile calcium binding sites are provided by structural proteins bound to the cytoskeleton or intracellular membranes and may thereby be relatively similar in composition and capacity across different cell types. However, recent evidence suggests that the immobile buffering capacity can vary greatly between cell types and that some mobile calcium binding proteins may alter their mobility upon binding calcium, thus blurring the line between mobile and immobile. The ways in which immobile buffering capacity might be relevant to different calcium domains within neurons has been explored primarily through modeling. In certain regimes, the presence of immobile buffers and the interaction between mobile and immobile buffers have been shown to result in complex spatiotemporal patterns of free calcium. ...Continue Reading

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Citations

Jun 23, 2016·Journal of Biological Rhythms·Robert Y Moore
Jul 31, 2020·ELife·Tuomo Mäki-MarttunenKim T Blackwell
Jul 22, 2019·The Journal of General Physiology·Miriam BellPadmini Rangamani
Jun 7, 2020·Journal of Molecular Neuroscience : MN·Yogesh Kumar Dhuriya, Divakar Sharma
Jan 10, 2019·The Journal of Biological Chemistry·Jonathan G Murphy, Dax A Hoffman
Aug 14, 2019·Scientific Reports·Andrea CugnoPadmini Rangamani
Sep 3, 2020·Nature Reviews. Neuroscience·Alexey SemyanovAmit Agarwal
Nov 11, 2016·Journal of Neurophysiology·Michael W Country, Michael G Jonz
Oct 27, 2020·Frontiers in Cellular Neuroscience·Nicholas M BannonMaxim Volgushev
Mar 28, 2021·Biophysical Journal·Yinbo Chen, Victor Matveev
Sep 28, 2021·Frontiers in Neuroscience·Sridevi NagarajaJaques Reifman

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