Bugs, drugs, and cancer: can the microbiome be a potential therapeutic target for cancer management?

Drug Discovery Today
Biying ChenYanjie Zhang

Abstract

Outnumbering our own cells over ten times, gut microbes can even be considered an additional organ. Several studies have explored the association between microbiomes and antitumor drug response. It has been reported that the presence of specific bacteria might modulate cancer progression and the efficacy of anticancer therapeutics. Bacteria-targeting intervention can provide crucial guidance for the design of next-generation antitumor drugs. Here, we review previous findings elucidating the impact of gut microbiomes on cancer treatment and the possible underlying mechanisms. In addition, we examine the role of microbiome manipulation in controlling tumor growth. Finally, we discuss concerns regarding the alteration of the microbiome composition, and the potential approaches to surpass existing limitations.

Citations

Nov 22, 2020·Nature Reviews. Clinical Oncology·Naohiko AkimotoShuji Ogino
Feb 27, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer BorowskyShuji Ogino

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