Building a bridge: engineering spinal cord repair

Experimental Neurology
Herbert M Geller, James W Fawcett

Abstract

Injuries to the spinal cord that result in disruption of axonal continuity have devastating consequences for injured patients. Current therapies that use biologically active agents to promote neuronal survival and/or growth have had modest success in allowing injured neurons to regrow through the area of the lesion. Strategies for successful regeneration will require an engineering approach. We propose the design of cell-free grafts of biocompatible materials to build a bridge across the injured area through which axons can regenerate. There are three critical regions of this bridge: the on-ramp, the surface of the bridge itself, and the off-ramp. Each of these regions has specific design requirements, which, if met, can promote regeneration of axons in the injured spinal cord. These requirements, and proposed solutions, are discussed.

References

Apr 1, 1992·Journal of Neurobiology·D M Snow, P C Letourneau
Nov 1, 1990·The Journal of Cell Biology·S R HeidemannR E Buxbaum
May 7, 1990·Brain Research·E M PowellW M Saltzman
Jan 1, 1986·Journal of Biomedical Materials Research·R E MarchantE O Dillingham
Feb 1, 1981·Journal of the Neurological Sciences·I D DuncanP M Wood
Jan 1, 1995·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·K H LamP Nieuwenhuis
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A L PrietoK L Crossin
Jun 1, 1994·Progress in Neurobiology·P J EvansS E Mackinnon
Feb 1, 1994·Current Opinion in Neurobiology·P Doherty, F S Walsh
Feb 1, 1996·Experimental Neurology·C T MontgomeryJ A Robson
Apr 1, 1996·Molecular Neurobiology·L McKerracherC O Arregui
Jun 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A ScholzeA Faissner
Aug 1, 1995·Cell Adhesion and Communication·G R PhillipsK L Crossin
Aug 1, 1996·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·I H WhitworthG Terenghi
Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
Jan 1, 1997·Journal of Biomedical Materials Research·G G GiordanoD Lahiri-Munir
Jul 1, 1997·The European Journal of Neuroscience·G D SterneG Terenghi
Mar 1, 1997·Biology of the Cell·A Beauvais-Jouneau, J P Thiery
Sep 23, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P Caroni
Oct 10, 1997·Cell and Tissue Research·E T Stoeckli

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Citations

Dec 4, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Laura De LaporteLonnie D Shea
Sep 1, 2006·Seminars in Reproductive Medicine·Courtney B BerkholtzTeresa K Woodruff
Mar 23, 2007·Journal of Neurotrauma·Shuxin ZhangEric G Holmberg
Apr 25, 2006·Journal of Neurotrauma·D D Pearse, M B Bunge
Apr 25, 2006·Journal of Neurotrauma·Fernando Fidel Santos-BenitoAlmudena Ramón-Cueto
Jun 15, 2011·Journal of Neurotrauma·Joseph R LoverdeBryan J Pfister
May 6, 2008·Tissue Engineering. Part B, Reviews·Grace N Li, Diane Hoffman-Kim
Apr 23, 2009·Tissue Engineering. Part a·Yang YangLonnie D Shea
Aug 10, 2011·Tissue Engineering. Part a·Rachael MooneyMelissa Mahoney
May 14, 2009·Tissue Engineering. Part B, Reviews·Leann L NormanHelim Aranda-Espinoza
May 15, 2008·Journal of the Royal Society, Interface·Yinghui Zhong, Ravi V Bellamkonda
Jul 14, 2006·Artificial Organs·Yi-Cheng Huang, Yi-You Huang
May 5, 2010·Annual Review of Biomedical Engineering·Diane Hoffman-KimRavi V Bellamkonda
Nov 27, 2009·Journal of Biomedical Science·Anuradha SubramanianSwaminathan Sethuraman
Mar 4, 2014·PloS One·Daniela Nogueira RochaAna Paula Pêgo
Apr 9, 2014·Annals of Biomedical Engineering·Robert D AdamsAmy B Harkins
Jul 17, 2013·Advanced Drug Delivery Reviews·Alessandra FabbroLaura Ballerini
Feb 2, 2006·In Vitro Cellular & Developmental Biology. Animal·Mainak DASJames J Hickman
Aug 26, 2006·Journal of Materials Science. Materials in Medicine·Ernesto Doncel-PérezEduardo Ruiz-Hitzky
Apr 27, 2012·Journal of Materials Science. Materials in Medicine·Jorge Luis Escobar IviricoManuel Monleón Pradas
Dec 20, 2002·Current Opinion in Neurobiology·V Reggie Edgerton, Roland R Roy
Jan 29, 2016·Journal of Neuroscience Methods·Dylan A McCreedyLonnie D Shea
Jun 1, 2010·Expert Opinion on Drug Discovery·Arjan P Quist, Sven Oscarsson
Feb 7, 2013·Journal of Neuroscience Methods·Jennifer A MitchelDiane Hoffman-Kim
Mar 6, 2003·The Anatomical Record. Part B, the New Anatomist·Fernando F Santos-Benito, Almudena Ramón-Cueto
Nov 14, 2015·Tissue Engineering. Part C, Methods·Chun LiuChristina Chan
Oct 19, 2011·Acta Biomaterialia·N DavidenkoR E Cameron
Jul 3, 2010·Science China. Life Sciences·ZhaoYang YangXiaoGuang Li
Mar 9, 2010·Biomaterials·Seungjin ShinLonnie D Shea

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