Building a FP-CIT SPECT Brain Template Using a Posterization Approach

Neuroinformatics
D Salas-GonzalezElmar W Lang

Abstract

Spatial affine registration of brain images to a common template is usually performed as a preprocessing step in intersubject and intrasubject comparison studies, computer-aided diagnosis, region of interest selection and brain segmentation in tomography. Nevertheless, it is not straightforward to build a template of [123I]FP-CIT SPECT brain images because they exhibit very low intensity values outside the striatum. In this work, we present a procedure to automatically build a [123I]FP-CIT SPECT template in the standard Montreal Neurological Institute (MNI) space. The proposed methodology consists of a head voxel selection using the Otsu's method, followed by a posterization of the source images to three different levels: background, head, and striatum. Analogously, we also design a posterized version of a brain image in the MNI space; subsequently, we perform a spatial affine registration of the posterized source images to this image. The intensity of the transformed images is normalized linearly, assuming that the histogram of the intensity values follows an alpha-stable distribution. Lastly, we build the [123I]FP-CIT SPECT template by means of the transformed and normalized images. The proposed methodology is a fully automat...Continue Reading

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Citations

Dec 7, 2017·Frontiers in Neuroinformatics·Diego Castillo-BarnesDiego Salas-Gonzalez
Sep 16, 2017·Annals of Nuclear Medicine·Atsutaka OkizakiKoji Takahashi
Dec 1, 2017·Frontiers in Neuroinformatics·Francisco J Martinez-MurciaDiego Salas-Gonzalez
Oct 31, 2018·Theoretical Biology & Medical Modelling·Lei Huang, Tong Wu
Sep 15, 2018·International Journal of Neural Systems·Francisco J Martinez-MurciaAndres Ortiz
Dec 13, 2016·Cell Transplantation·Weyland Cheng, Peter K Law
Aug 14, 2020·International Journal of Neural Systems·Diego Castillo-BarnesJuan M Górriz
Sep 11, 2018·Journal of Clinical Neurology·Nicolas NicastroArmin Schnider
May 16, 2019·International Journal of Neural Systems·Fermín SegoviaDiego Castillo-Barnes
Jul 18, 2019·Frontiers in Neuroinformatics·Andrés OrtizDiego Salas-Gonzalez
Oct 17, 2018·International Journal of Neural Systems·Andrés OrtizJavier Ramírez

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