Building A New Treatment For Heart Failure-Transplantation of Induced Pluripotent Stem Cell-derived Cells into the Heart

Current Gene Therapy
Shigeru MiyagawaYoshiki Sawa

Abstract

Advanced cardiac failure is a progressive intractable disease and is the main cause of mortality and morbidity worldwide. Since this pathology is represented by a definite decrease in cardiomyocyte number, supplementation of functional cardiomyocytes into the heart would hypothetically be an ideal therapeutic option. Recently, unlimited in vitro production of human functional cardiomyocytes was established by using induced pluripotent stem cell (iPSC) technology, which avoids the use of human embryos. A number of basic studies including ours have shown that transplantation of iPSCderived cardiomyocytes (iPSC-CMs) into the damaged heart leads to recovery of cardiac function, thereby establishing "proof-of-concept" of this iPSC-transplantation therapy. However, considering clinical application of this therapy, its feasibility, safety, and therapeutic efficacy need to be further investigated in the pre-clinical stage. This review summarizes up-to-date important topics related to safety and efficacy of iPSC-CMs transplantation therapy for cardiac disease and discusses the prospects for this treatment in clinical studies.

Citations

Jun 19, 2018·Cardiovascular Research·Maaike Yldau van der EndePim van der Harst
Mar 4, 2017·Circulation Research·Thomas Doetschman, Teodora Georgieva
Aug 20, 2016·Nature Reviews. Cardiology·Shigeo MasudaYoshiki Sawa
May 31, 2021·Journal of Bioscience and Bioengineering·Riku Yamamoto, Masahiro Kino-Oka

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Methods Mentioned

BETA
X-ray
flow cytometry

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