Building an integrated model of chromosome congression

Journal of Cell Science
Philip Auckland, Andrew D McAinsh

Abstract

A universal feature of mitosis is that all chromosomes become aligned at the spindle equator--the halfway point between the two spindle poles--prior to anaphase onset. This migratory event is called congression, and is powered by centromere-bound protein machines called kinetochores. This Commentary aims to document recent advances concerning the two kinetochore-based force-generating mechanisms that drive mitotic chromosome congression in vertebrate cells: depolymerisation-coupled pulling (DCP) and lateral sliding. We aim to explore how kinetochores can 'read-out' their spatial position within the spindle, and adjust these force-generating mechanisms to ensure chromosomes reach, and then remain, at the equator. Finally, we will describe the 'life history' of a chromosome, and provide a working model for how individual mechanisms are integrated to ensure efficient and successful congression.

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Citations

Feb 24, 2016·Frontiers in Plant Science·Marie-Edith Chabouté, Alexandre Berr
Jun 28, 2016·Trends in Cell Biology·Marin Barisic, Helder Maiato
Aug 15, 2017·Nature Chemical Biology·Huaiying ZhangMichael A Lampson
Jun 25, 2017·The EMBO Journal·Sebastian PünzelerSandra B Hake
Jan 25, 2019·The Journal of Cell Biology·Devashish DwivediMahak Sharma
Oct 9, 2019·The Journal of Chemical Physics·Cheng-Tai Lee, Eugene M Terentjev
Aug 18, 2018·Journal of Cell Science·Julie K Monda, Iain M Cheeseman
Aug 30, 2018·Journal of Cell Science·Kirsten GarnerSarah Woolner
Aug 9, 2019·Annual Review of Cell and Developmental Biology·Mithila Burute, Lukas C Kapitein
May 13, 2017·The Journal of Cell Biology·Philip AucklandAndrew D McAinsh
Oct 6, 2018·Essays in Biochemistry·Alexander James ZwetslootAnne Straube
Apr 4, 2021·International Journal of Molecular Sciences·Ayumu Yamamoto

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