Building blocks for bispecific and trispecific antibodies

Methods : a Companion to Methods in Enzymology
Xiufeng Wu, Stephen J Demarest

Abstract

Bispecific antibodies (BsAbs), which target two antigens or epitopes, incorporate the specificities and properties of two distinct monoclonal antibodies (mAbs) into a single molecule. As such, BsAbs can elicit synergistic activities and provide the capacity for enhanced therapeutic efficacy and/or safety compared to what can be achieved with conventional monospecific IgGs. There are many building block formats to generate BsAbs and Trispecific antibodies (TsAbs) based on combining the antigen recognition domains of monoclonal antibodies (mAbs). This review describes the many and varied antibody-based building blocks used to achieve multivalency and multispecificity. These diverse building blocks provide opportunities to tailor the design of BsAbs and TsAbs to match the desired applications.

Citations

Aug 11, 2019·Current Pharmaceutical Biotechnology·Miriam DiboLígia C Faccin-Galhardi
Apr 11, 2019·Nature Reviews. Rheumatology·Samuel J S RubinWilliam H Robinson
Jul 30, 2020·International Journal of Molecular Sciences·Lucille LamendourFlorence Velge-Roussel
May 28, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Thomas Litman
Feb 11, 2020·Journal of Drug Targeting·Tongtong QiGuimei Lin
Feb 14, 2021·Journal of Alzheimer's Disease : JAD·Wim Hendricus QuintThomas Vogels
Dec 17, 2019·Current Opinion in Biotechnology·Christoph Rader
Jan 31, 2021·Nature Communications·Roland BeckmannHubert Kettenberger
Mar 9, 2021·Frontiers in Immunology·Mehdi MohammadiFazel Shokri
May 6, 2021·Oncogene·Rebecca S Goydel, Christoph Rader
Jan 29, 2022·Biological Chemistry·Veronica NataleGordana Wozniak-Knopp

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