Building protein interaction maps for Down's syndrome

Briefings in Functional Genomics & Proteomics
Katheleen J GardinerLinda S Crnic

Abstract

Now that the complete sequences for human chromosome 21 and the orthologous mouse genomic regions are known, reasonably complete, conserved, protein-coding gene catalogues are also available. The central issue now facing Down's syndrome researchers is the correlation of increased expression of specific, normal, chromosome 21 genes with the development of specific deficits in learning and memory. Because of the number of candidate genes involved, the number of alternative splice variants of individual genes and the number of pathways in which these genes function, a pathway analysis approach will be critical to success. Here, three examples, both gene specific and pathway related, that would benefit from pathway analysis are discussed: (1) the potential roles of eight chromosome 21 proteins in RNA processing pathways; (2) the chromosome 21 protein intersectin 1 and its domain composition, alternative splicing, protein interactions and functions; and (3) the interactions of ten chromosome 21 proteins with components of the mitogen-activated protein kinase and the calcineurin signalling pathways. A productive approach to developing gene-phenotype correlations in Down's syndrome will make use of known and predicted functions and in...Continue Reading

Citations

Apr 6, 2006·Behavior Genetics·Pierre L Roubertoux, Bernard Kerdelhué
Nov 28, 2008·Neuroscience Bulletin·Ning MaYong-Jie Ma
Jul 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Avi Ma'ayanRavi Iyengar
Jan 5, 2012·Journal of Proteome Research·Md Mahiuddin AhmedKatheleen J Gardiner
Jan 8, 2009·Genes, Brain, and Behavior·A SiddiquiK J Gardiner
May 6, 2010·American Journal on Intellectual and Developmental Disabilities·Mohammed Rachidi, Carmela Lopes
Apr 6, 2006·PLoS Genetics·Randall J Roper, Roger H Reeves
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