Building the spine: the vertebrate segmentation clock

Cold Spring Harbor Symposia on Quantitative Biology
Olivier Pourquié

Abstract

One of the most striking characteristics of many animal and plant species is their organization in a series of periodically repeated anatomical modules. In animals, this particular patterning strategy of the body axis is termed segmentation, and it is observed in both vertebrates and invertebrates. Vertebrate segmentation has been associated with a molecular oscillator-the segmentation clock-whose existence had been predicted on theoretical grounds in the clock and wave-front model. The segmentation clock is proposed to generate pulses of signaling used for the positioning of segmental boundaries. Whereas several models have proposed that simple negative autoregulatory circuits involving the transcription repressors of the hairy and enhancer of split family constitute the clock pacemaker, recent microarray studies in mouse have identified a large network of oscillating signaling genes belonging to the Notch, Wnt, and FGF (fibroblast growth factor) pathways. Thus, significant progress has been made, but the molecular nature of the clockwork underlying the oscillator remains poorly understood. Few examples of oscillators exist in developmental biology, and the segmentation clock provides a unique model of periodic regulation in p...Continue Reading

References

Dec 28, 1999·Trends in Cell Biology·G K Davis, N H Patel
Jan 29, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K J Dale, O Pourquié
Mar 22, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Y BesshoR Kageyama
Jun 29, 2001·Mechanisms of Development·V E PrinceT F Vogt
Oct 20, 2001·Genes & Development·Y BesshoR Kageyama
Nov 1, 2001·Annual Review of Cell and Developmental Biology·O Pourquié
Nov 21, 2001·Nature Reviews. Genetics·Y Saga, H Takeda
Feb 1, 2003·Differentiation; Research in Biological Diversity·Yan LiNicolas Pollet
Mar 15, 2003·Developmental Cell·Alexander AulehlaBernhard G Herrmann
Aug 23, 2003·Current Biology : CB·Olivier Pourquié, Albert Goldbeter
Dec 31, 2003·Developmental Biology·Padmashree C G RidaYun Jin Jiang
May 4, 2004·American Journal of Human Genetics·Neil V WhittockPeter D Turnpenny
Sep 3, 2004·Genes & Development·Alexander Aulehla, Bernhard G Herrmann
Nov 10, 2004·Journal of Biological Rhythms·Jay C Dunlap, Jennifer J Loros
Nov 13, 2004·Development·Julien Dubrulle, Olivier Pourquié
May 21, 2005·The International Journal of Developmental Biology·Miguel MarotoOlivier Pourquié
Aug 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Marie-Claire DelfiniOlivier Pourquié
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yoshito MasamizuRyoichiro Kageyama
Jun 9, 2006·Nature·Kazuki HorikawaHiroyuki Takeda
Nov 11, 2006·Science·Mary-Lee DequéantOlivier Pourquié
Mar 31, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yumiko Saga
Apr 11, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kana IshimatsuHiroyuki Takeda
Apr 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Julian Lewis, Ertugrul M Ozbudak
May 9, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Scott A Holley
May 15, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Albert GoldbeterOlivier Pourquié
May 15, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Paul M KulesaPhilip K Maini
May 15, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Peter D TurnpennySally Dunwoodie

❮ Previous
Next ❯

Citations

Mar 21, 2009·Development, Growth & Differentiation·Alessandra Pierani, Marion Wassef
Apr 10, 2015·PloS One·Katrin SerthAchim Gossler
Feb 5, 2019·PLoS Computational Biology·Honda NaokiTakaaki Matsui
Apr 2, 2010·American Journal of Medical Genetics. Part a·Beth MarosyNancy H Miller
Mar 14, 2018·Scientific Reports·Dini Wahyu Kartika SariTakaaki Matsui
Jun 10, 2011·Development·Gavin J WrightJulian Lewis

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.