Bulbospinal projections in the primate: a light and electron microscopic study of a pain modulating system

The Journal of Comparative Neurology
A I BasbaumH J Ralston

Abstract

The projections of the nucleus raphe magnus (NRM) and the immediately adjacent reticular formation were studied in the macaque monkey following injections of the rostroventral medulla with 3H-leucine and examination of the resultant labeled axons and terminals by light and electron microscopic autoradiography. Five monkeys had accurately placed injections, which resulted in fiber pathway labeling that coursed caudally, laterally, and dorsally to project to laminae I, II, and V of subnucleus caudalis of the trigeminal and then traveled in the dorsolateral funiculus of the cord and terminated in similar laminae of the spinal dorsal horn at cervical levels. The pathway was only lightly labeled caudal to the cervical enlargement and could not be readily discerned above background in the thoracic or lumbar cord. Electron microscopy revealed that axons and terminals serving this system constitute a heterogeneous population. Large-diameter myelinated axons (3-6-micron diameter), small myelinated axons (0.75-3-micron diameter), and clusters of nonmyelinated axons were labeled. Terminals in laminae I, II, and V contained mixtures of clear round and granular vesicles or clear pleomorphic and granular vesicles or formed the central elemen...Continue Reading

References

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Citations

Oct 12, 2001·The Journal of Comparative Neurology·K Gao, P Mason
Feb 1, 1992·Electroencephalography and Clinical Neurophysiology·K ShimojiT Hokari
Nov 24, 1999·Brain Research Bulletin·C R MonassiL Menescal-de-Oliveira
Aug 5, 1998·British Journal of Pharmacology·T L XuN Akaike
Jan 17, 2009·Brain Research Reviews·M M HeinricherB M Lumb
Jan 1, 1997·Archives of Physical Medicine and Rehabilitation·G A Mellick, L B Mellick
Feb 26, 1999·Journal of Neurophysiology·C G Leung, P Mason
Dec 15, 2012·Pharmacological Reports : PR·Jakub FichnaMartin A Storr
Aug 8, 1989·The Journal of Comparative Neurology·E Bullitt, A R Light
Apr 1, 1988·The Journal of Comparative Neurology·J C Glover, G Petursdottir
Nov 23, 2016·Sexual Medicine Reviews·Gert Holstege

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