Bulk and dispersed aqueous behaviour of an endogenous lipid, selachyl alcohol: Effect of Tween 80 and Pluronic F127 on nanostructure

Colloids and Surfaces. B, Biointerfaces
Mohammad YounusS B Rizwan

Abstract

Tween 80 has been reported to provide a means of targeting drug nanocarriers to the blood- brain barrier. This study investigated the influence of addition of Tween 80 on the formation of different bulk and dispersed lyotropic liquid crystalline phases in selachyl alcohol-based systems. The effect of increasing concentrations of Tween 80 and Pluronic F127 (as a control) (0-25% w/w relative to SA) on the bulk phase behaviour and dispersions of selachyl alcohol (SA) were investigated using small angle X-ray scattering, dynamic light scattering, and cryogenic transmission electron microscopy. The addition of Tween 80 to SA bulk phase samples triggered concentration-dependent phase changes with the structure sequentially evolving from a reverse hexagonal phase (H2) to a mixed H2 and inverse bicontinuous cubic (V2) then a V2 phase alone. In contrast, the addition of Pluronic F127 resulted in a phase change from H2 phase to a mixed lamellar and H2 phase system. The mean particle size of internally structured particles was 125-190 nm with low polydispersity indices (0.1-0.2). Nanoparticles retained the bulk phase internal structure in the presence of Tween 80, whereas in the presence of Pluronic F127, the additional lamellar phase tha...Continue Reading

Citations

Sep 5, 2020·Expert Opinion on Drug Delivery·Ana Vitoria Pupo SilvestriniMaria Vitoria Lopes Badra Bentley
Sep 17, 2020·Drug Delivery and Translational Research·Gisela RamirezBen J Boyd
Apr 11, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ghita ToutiChrystel Faure
Mar 7, 2021·International Journal of Pharmaceutics·H AzhariShakila B Rizwan
Jul 27, 2021·Journal of Colloid and Interface Science·Younus MohammadShakila B Rizwan

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