Bulk Flow and Near Wall Hemodynamics of the Rabbit Aortic Arch: A 4D PC-MRI Derived CFD Study

Journal of Biomechanical Engineering
David MolonyAmir Rezvan

Abstract

Animal models offer a flexible experimental environment for studying atherosclerosis. The mouse is the most commonly used animal, however, the underlying hemodynamics in larger animals such as the rabbit are far closer to that of humans. The aortic arch is a vessel with complex helical flow and highly heterogeneous shear stress patterns which may influence where atherosclerotic lesions form. A better understanding of intra-species flow variation and the impact of geometry on flow may improve our understanding of where disease forms. In this work we use Magnetic Resonance Angiography (MRA) and 4D Phase contrast magnetic resonance imaging (PC-MRI) to image and measure blood velocity in the rabbit aortic arch. Measured flow rates from the PC-MRI were used as boundary conditions in computational fluid dynamics models of the arches. Helical flow, cross flow index (CFI) and time-averaged wall shear stress (TAWSS) were determined from the simulated flow field. Both traditional geometric metrics and shape modes derived from statistical shape analysis were analyzed with respect to flow helicity. High CFI and low TAWSS were found to co-localize in the ascending aorta and to a lesser extent on the inner curvature of the aortic arch. The R...Continue Reading

References

May 1, 1984·Atherosclerosis·R G Kratky, M R Roach
Nov 1, 1993·Journal of Biomechanical Engineering·D P GiddensS Glagov
Aug 22, 2003·Journal of Biomechanical Engineering·Suo JinDon P Giddens
Apr 22, 2006·Journal of Biomechanics·Umberto MorbiducciAlberto Redaelli
Oct 19, 2006·Journal of Biomechanics·Peter D Weinberg, C Ross Ethier
Jul 24, 2010·Biomechanics and Modeling in Mechanobiology·Umberto MorbiducciAlberto Redaelli
May 20, 2011·Journal of the Royal Society, Interface·P E VincentS J Sherwin
Mar 3, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Godfrey S Getz, Catherine A Reardon
Aug 3, 2012·Journal of Biomechanics·Diego GalloUmberto Morbiducci
Jul 30, 2014·Journal of Biomechanical Engineering·Mark Van DoormaalR Mark Henkelman
Aug 11, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Petter DyverfeldtMichael Markl
Nov 26, 2015·Journal of Biomechanical Engineering·Amirhossein Arzani, Shawn C Shadden
Jun 2, 2016·BMC Medical Imaging·Jan L BruseUNKNOWN Modeling of Congenital Hearts Alliance (MOCHA) Collaborative Group
Nov 20, 2016·Journal of Biomechanics·Yumnah MohamiedPeter D Weinberg

❮ Previous
Next ❯

Citations

Feb 10, 2021·Journal of the Royal Society, Interface·Amirhossein Arzani, Scott T M Dawson
Mar 7, 2021·Biomedicines·Kristina AndelovicAlma Zernecke
Jul 31, 2021·International Journal of Computer Assisted Radiology and Surgery·Michael LauriaAnand Santhanam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.