Bulk modification of polymeric microfluidic devices

Lab on a Chip
Joseph WangSafwan Obeidat

Abstract

The surface properties of microfluidic devices play an important role in their flow behavior. We report here on an effective control of the surface chemistry and performance of polymeric microchips through a bulk modification route during the fabrication process. The new protocol is based on modification of the bulk microchip material by tailored copolymerization of monomers during atmospheric-pressure molding. A judicious addition of a modifier to the primary monomer solution thus imparts attractive properties to the plastic microchip substrate, including significant enhancement and/or modulation of the EOF (with flow velocities comparable to those of glass), a strong pH sensitivity and high stability. Carboxy, sulfo, and amino moieties have thus been introduced (through the incorporation of methylacrylic acid, 2-sulfoethyl-methacrylate and 2-aminoethyl-methacrylate monomers, respectively). A strong increase in the electroosmotic pumping compared to the native poly(methylmethacrylate)(PMMA) microchip (ca. electroosmotic mobility increases from 2.12 to 4.30 x 10(-4) cm(2) V(-1) s(-1)) is observed using a 6% methylacrylate (MAA) modified PMMA microchip. A 3% aminoethyl modified PMMA microchip exhibits a reversal of the electroos...Continue Reading

References

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Citations

Sep 15, 2007·Electrophoresis·Yan XiaoHong-Yuan Chen
Dec 12, 2007·Electrophoresis·Patrick AbgrallNam-Trung Nguyen
Feb 3, 2007·Lab on a Chip·Yan XuKazuhiko Ishihara
Aug 18, 2010·Molecular BioSystems·Malinda SalimPhillip C Wright

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