Bulk pollen sequencing reveals rapid evolution of segregation distortion in the male germline of Arabidopsis hybrids

Evolution Letters
Russell Corbett-DetigVincent Castric

Abstract

Genes that do not segregate in heterozygotes at Mendelian ratios are a potentially important evolutionary force in natural populations. Although the impacts of segregation distortion are widely appreciated, we have little quantitative understanding about how often these loci arise and fix within lineages. Here, we develop a statistical approach for detecting segregation distorting genes from the comprehensive comparison of whole genome sequence data obtained from bulk gamete versus somatic tissues. Our approach enables estimation of map positions and confidence intervals, and quantification of effect sizes of segregation distorters. We apply our method to the pollen of two interspecific F1 hybrids of Arabidopsis lyrata and A. halleri and we identify three loci across eight chromosomes showing significant evidence of segregation distortion in both pollen samples. Based on this, we estimate that novel segregation distortion elements evolve and achieve high frequencies within lineages at a rate of approximately one per 244,000 years. Furthermore, we estimate that haploid-acting segregation distortion may contribute between 10% and 30% of reduced pollen viability in F1 individuals. Our results indicate haploid acting factors evolve...Continue Reading

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Citations

Jan 29, 2020·Journal of Evolutionary Biology·Graeme L KeaisSteve J Perlman
Mar 23, 2021·Trends in Genetics : TIG·Ethan Bier, Victor Nizet
Aug 8, 2021·Nature Reviews. Genetics·Ethan Bier

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Datasets Mentioned

BETA
PRJNA503733

Methods Mentioned

BETA
genotyping

Software Mentioned

GitHub
BWA
Genome Analysis Toolkit
Trimmomatic

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