Bulky Early-Stage Cervical Cancer (2-4 cm Lesions): Upfront Radical Trachelectomy or Neoadjuvant Chemotherapy Followed by Fertility-Preserving Surgery: Which Is the Best Option?

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Marie Plante

Abstract

Radical trachelectomy is now recognized as a valid treatment option for young women with early-stage cervical cancer with lesions measuring less than 2 cm. However, for women with bulky lesions measuring greater than 2 cm, few data are available in the literature to guide management. There are currently 2 options available: either upfront radical trachelectomy or neoadjuvant chemotherapy followed by fertility-preserving surgery. Overall, both options offer very good oncologic outcome; however, the rate of fertility preservation and obstetrical outcome seem superior after neoadjuvant chemotherapy. Advantages and disadvantages of both options are discussed and a thorough literature review is provided. Issues to be further studied are also outlined.

References

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May 15, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Marie PlanteMichel Roy
May 30, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Stephanie L WethingtonNadeem R Abu-Rustum
Jun 1, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Balazs LintnerLaszlo Ungar
Jun 26, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Marie Plante
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Citations

Jan 16, 2016·Journal of Surgical Oncology·Erin E MedlinLisa Barroilhet
Apr 15, 2016·The Journal of Obstetrics and Gynaecology Research·Miseon KimTsuyoshi Saito
May 26, 2016·Journal of Surgical Oncology·Min-Hyun BaekJoo-Hyun Nam
Jun 13, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Robert PókaZoltán Hernádi
Nov 28, 2018·Journal of Gynecologic Oncology·Jacobus van der Velden, Constantijne H Mom
Feb 12, 2019·Journal of Gynecologic Oncology·Tae Wook KongSeob Jeon
Nov 8, 2018·Molecular and Clinical Oncology·Blanca Gil-IbañezBerta Diaz-Feijoo
Feb 27, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mary McCormackMarie Plante
Mar 3, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Florencia NollFernando Heredia
Mar 3, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Javier BurbanoJuliana Rodriguez
Mar 7, 2021·Cancers·Teska SchuurmanChristianne Lok
Mar 24, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jenneke C KasiusConstantijne H Mom
Feb 26, 2019·American Journal of Obstetrics and Gynecology·Koji MatsuoJason D Wright
Feb 14, 2018·ACS Applied Materials & Interfaces·Jian LiYan-Qing Guan

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