Bullous amyloidosis in a horse: first description in veterinary medicine.

Veterinary Dermatology
Devin FussellKeith E Linder

Abstract

Bullous amyloidosis is a rare disease in humans that has not been described in a veterinary species in the peer-reviewed literature. The human disease is characterised by haemorrhagic vesicles and bullae on the skin and mucosae, which form due to amyloid deposition. To describe the clinical features, laboratory analysis and histopathological features of an unique presentation of bullous disease in a horse. A 17-year-old thoroughbred mare presented for weight loss and severe oral cavity ulcers. Investigations involved haematological evaluation, chemistry profiles, gastroscopy and serum protein electrophoresis, and, postmortem, histopathological evaluation, Congo-red staining and transmission electron microscopy (TEM). Haemorrhagic vesicles and bullae occurred on the mucosa of the oral cavity, lips, oesophagus and stomach, and much less the muzzle, face and mucocutaneous areas of the perineum, where scarring was evident. Histopathological evaluation and Congo-red staining confirmed the presence of amyloid deposits in dermis and submucosa, in association with vesicle and bulla formation, consistent with bullous amyloidosis. TEM confirmed amyloid fibril deposition in the dermis and along the basement membrane zone. Clefts occurred ...Continue Reading

References

Jul 1, 1988·Equine Veterinary Journal·A C van AndelJ Veerkamp
Feb 1, 1988·Journal of Comparative Pathology·D W HaydenP Westermark
Jan 15, 2010·European Journal of Dermatology : EJD·Stephan SchremlPhilipp Babilas
May 12, 2012·Veterinary Medicine International·Moges Woldemeskel
Dec 21, 2019·BMC Veterinary Research·Stine JacobsenLise Nikolic Nielsen
Mar 20, 2020·Sub-cellular Biochemistry·George H Sack

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