Bullous hemorrhagic dermatosis at distant sites: a report of 2 new cases due to enoxaparin injection and a review of the literature

Actas dermo-sifiliográficas
C A VillanuevaJ Borbujo

Abstract

Enoxaparin is a low-molecular-weight heparin used in the prevention and treatment of pulmonary thromboembolism and other thrombotic disorders. The most common adverse reactions to enoxaparin are ecchymosis, skin necrosis, urticaria, angioedema, and eczema. The first 2 cases of bullous hemorrhagic dermatosis in areas distant from heparin injection sites were described in 2006. We present the cases of 2 men, aged 68 and 78 years, with progressive, advanced-stage lung cancer, who consulted with bullous hemorrhagic lesions without associated symptoms. Both patients reported that the lesions had appeared after initiation of heparin therapy at therapeutic doses. In our review of the literature, we found just 7 cases of heparin-induced bullous hemorrhagic dermatosis. We report a further 2 cases, caused by enoxaparin, in which treatment was continued and in which the lesions resolved in 2 to 3 weeks.

References

Jan 24, 2006·Journal of the American Academy of Dermatology·Adeline PerrinaudLaurent Machet
May 7, 2009·The British Journal of Dermatology·H BeltraminelliL Cerroni
May 20, 2009·Archives of Dermatology·Urvi Pajvani GonzalesAlice P Pentland

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Citations

Mar 19, 2014·Medicina clínica·Leire Loidi PascualIgnacio Yanguas Bayona
May 6, 2015·Cutaneous and Ocular Toxicology·Ana Isabel GouveiaPaulo Filipe
Sep 10, 2014·Cutaneous and Ocular Toxicology·Savaş OztürkOzgen Aslan Solmaz
Dec 25, 2015·Medicina clínica·María Castellanos-GonzálezAna Belén Mancebo Plaza
Mar 2, 2016·Hospital Practice·Bhuvanesh GovindLuis Eraso
Dec 29, 2017·Clinical and Experimental Dermatology·S C SnowL Golitz
Jun 10, 2017·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Sumeet Prakash Mirgh, Abhay A Bhave
Jun 12, 2013·The Australasian Journal of Dermatology·Shreya DixitAdrian Lim
Oct 24, 2017·International Journal of Dermatology·Claire E HamiltonJonathan S Leventhal
May 11, 2017·Asia Pacific Allergy·Ji-Su ShimYoon-Seok Chang
Dec 1, 2019·Medicina clínica·Ignacio Torres-NavarroConrad Pujol-Marco
Apr 3, 2021·The American Journal of Dermatopathology·Rita Fernanda Cortez de AlmeidaThiago Jeunon

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