PMID: 9173060Feb 1, 1997Paper

Bullous mastocytosis in a child

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
U F Haustein, M Bedri

Abstract

We report a case of bullous mastocytosis in a 30-month-old girl, who developed disseminated pruritic urticarial and bullous lesions on the trunk accompanied by episodes of vomiting and generalized flushing. Her problems began at the age of 6 months. Her stool was repeatedly positive for occult blood. Histamine and 5-hydroxytryptamine were measured in the urine and serum; urine 5-hydroxytryptamine levels were elevated. In addition, trypsin and chymotrypsin levels were raised in the blister fluid. Metachromatic staining of the mast cells in a skin biopsy specimen confirmed the diagnosis. A combination of oral disodium cromoglycate and ketotifen produced a dramatic improvement of the cutaneous and gastrointestinal features.

Citations

Feb 5, 2003·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M VogelD Abeck
Jun 15, 2011·American Journal of Clinical Dermatology·Mariana CastellsLuis Escribano
Jul 26, 2000·Hematology/oncology Clinics of North America·A S Worobec

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