PMID: 7036909Jan 1, 1982Paper

Bullous pemphigoid and antinuclear antibodies. Unmasking of basement membrane fluorescence in sodium chloride-treated substrates

Archives of Dermatology
K DannoS Imamura

Abstract

Immunoflourescent (IF) microscopic studies were done on a patient with bullous pemphigoid who had a high titer of antinuclear antibodies (ANAs). Direct IF microscopy showed deposition of lgG and C3 at the basement membrane zone (BMZ), while, by indirect IF microscopy, ANAs (but not circulating pemphigoid antibodies) were detected. The 2M sodium chloride (NaCl) solution-treated substrates, in which nuclear antigens were eluted, uncovered pemphigoid antibodies. Treatment of the substrates with NaCl solution unmasked BMZ fluorescence in another set of experiments in which a large amount of serum samples containing ANAs was added to serum samples containing only pemphigoid antibodies. These results suggest that pemphigoid antibodies are able to react to the BMZ in the presence of concomitant ANAs unless bind to the nuclear antigens.

Citations

Apr 1, 1991·Journal of the American Academy of Dermatology·C K JannigerR A Schwartz
Jan 1, 1987·Clinics in Dermatology·M J ImberR E Jordon
May 1, 1990·The Journal of the Association of Physicians of India·T K JagadishG R Bhangui
Jan 27, 2015·Autoimmunity Reviews·Emanuele CozzaniAurora Parodi
Nov 5, 2015·Reports on Progress in Physics·Thomas A Vilgis
Jun 1, 1989·International Journal of Dermatology·M G FlemingL A Weber

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bullous Pemphigoid

Bullous pemphigoid is a rare immune system disorder and skin condition that causes large, fluid-filled blisters. Bullous pemphigoid commonly affects older adults and appears in areas such as the lower abdomen, upper thighs or armpits. Discover the latest research on bullous pemphigoid here.