PMID: 8608345Dec 1, 1995Paper

Bullous pemphigoid: serum antibody titre and antigen specificity

Experimental Dermatology
H H PasJ B van der Meer

Abstract

2 antigens have been identified as possible targets for autoantibody depositions in bullous pemphigoid: a 230-kD protein (BP230) and a 180-kD protein (BP180). We studied the relationship of these 2 antigens with the immunofluorescence determined serum antibody titre: 2 groups of bullous pemphigoid patients were selected on the basis of immunoblot-determined antibody specificity. One group (13 patients) had antibody specificity for BP230 and not for BP180, while the other group (9 patients) had antibody specificity for BP180 and not for BP230. The immunofluorescence titres of the circulating antibodies determined on monkey oesophagus substrate displayed, for the BP230-specific group, a mean of 1:1102. The maximal observed titre was 1:5120. The mean titre in the BP180-specific group was only 1:29, with a highest titre of only 1:160. This result suggests that in routine indirect immunofluorescence of bullous pemphigoid sera, the contribution of the BP180-specific antibodies to the total anti-epidermal basement membrane zone antibody titre is relatively much lower than that of the BP230-specific antibodies. Thus, at high dilutions, only the BP230-specific antibodies contribute to the overall indirect immunfluorescence titre.

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Citations

Feb 4, 1999·Oral Oncology·R I van der WaalC Nieboer
Jan 14, 1999·The Journal of Investigative Dermatology·H H PasM F Jonkman
Mar 29, 2002·The Journal of Investigative Dermatology·Petra H L Schuilenga-HutMarcel F Jonkman
Jun 24, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Giovanni Di ZenzoMichael Hertl
Jan 5, 2008·International Journal of Dermatology·Suying FengChanggeng Shao
Jun 26, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Enno SchmidtAlexander Nast
May 29, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·E Dabelsteen
Jun 22, 2002·Journal of the American Academy of Dermatology·Enno SchmidtDetlef Zillikens

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