Bullous pemphigoid with hyperkeratosis and palmoplantar keratoderma: Three cases

The Journal of Dermatology
Luca FaniaBiagio Didona

Abstract

The clinical features of bullous pemphigoid are extremely polymorphous. Several atypical forms of bullous pemphigoid have been described, and the diagnosis critically relies on immunopathological findings. We describe three bullous pemphigoid patients characterized by palmoplantar keratoderma, diffused hyperkeratotic cutaneous lesions and extremely high levels of immunoglobulin E serum. The diagnosis of bullous pemphigoid should be taken into account in patients presenting diffused hyperkeratotic cutaneous lesions and palmoplantar keratoderma, even in the absence of blisters. Alteration of the keratinization process, that could occur in patients with genetic mutations in desmosomal and hemidesmosomal genes, may also be due to circulating autoantibodies against hemidesmosomal proteins in these bullous pemphigoid patients.

References

Jan 1, 1987·Journal of the American Academy of Dermatology·E M RazackA Zahra
Sep 1, 1974·Archives of Dermatology·C E ArbesmanE H Beutner
Dec 28, 2007·Advances in Dermatology·Giovanni Di ZenzoLuca Borradori
Jun 24, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Giovanni Di ZenzoMichael Hertl
Dec 6, 2011·Clinics in Dermatology·Giovanni Di ZenzoLuca Borradori
Apr 27, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Luca FaniaMichael Hertl
Oct 9, 2012·Experimental Dermatology·Takahiro HamadaTakashi Hashimoto
Jan 27, 2015·Autoimmunity Reviews·Emanuele CozzaniAurora Parodi

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