Bullous pemphigoid

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
Franziska SchulzeE Schmidt

Abstract

Pemphigoid diseases are a group of autoimmune disorders characterized by subepidermal blistering and autoantibodies against structural proteins of the dermal-epidermal junction. In bullous pemphigoid, the most common subepidermal blistering autoimmune disease, antibodies are directed against the hemidesmosomal antigens BP180 (collagen type XVII) and BP230. Bullous pemphigoid typically presents with severe pruritus and tense blisters accompanied by erosions and crusts in elderly patients. Diagnostic landmarks are the detection of linear IgG and/or C3 deposits at the dermo-epidermal junction by direct immunofluorescence microscopy of a perilesional biopsy and the detection of serum autoantibodies by indirect immunofluorescence microscopy on human salt-split skin and ELISA employing recombinant immunodominant fragments of BP180 and BP230. Treatment options include topical (class IV) and/or systemic corticosteroids, frequently combined with immunomodulatory agents like dapsone and tetracyclines or immunosuppressants such as methotrexate and azathioprine.

References

Oct 27, 1997·The Journal of Investigative Dermatology·D ZillikensG J Giudice
Feb 1, 2002·The New England Journal of Medicine·Pascal JolyUNKNOWN Bullous Diseases French Study Group
Mar 29, 2002·The Journal of Investigative Dermatology·Cassian SitaruDetlef Zillikens
Jul 28, 2005·Clinical and Experimental Dermatology·J E Herrero-GonzálezD Zillikens
Feb 27, 2007·Nature Medicine·Wataru NishieHiroshi Shimizu
Oct 4, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Detlef ZillikensFabian Ziller
Jan 23, 2008·Archives of Dermatology·Yohei IwataShinichi Sato
Jun 24, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Giovanni Di ZenzoMichael Hertl
Jan 28, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Franziska BertramEnno Schmidt
Jul 2, 2009·The British Journal of Dermatology·G MarazzaUNKNOWN Autoimmune bullous disease Swiss study group
Dec 23, 2009·Current Drug Discovery Technologies·Michael Kasperkiewicz, Enno Schmidt
Jan 20, 2010·Archives of Dermatology·Carilyn N WielandJoseph A Murray
Aug 18, 2010·Autoimmunity Reviews·Enno Schmidt, Detlef Zillikens
Oct 15, 2010·The Journal of Investigative Dermatology·Sylvie Bastuji-GarinUNKNOWN French Study Group for Bullous Diseases
Nov 19, 2010·The Journal of Investigative Dermatology·Sinéad M LanganJoe West
Mar 15, 2011·Annales de dermatologie et de vénéréologie·P BernardUNKNOWN Centres de référence des maladies bulleuses auto-immunes. Société Française de Dermatologie
May 25, 2011·Dermatologic Clinics·Enno SchmidtLuca Borradori
May 25, 2011·Dermatologic Clinics·Hideyuki UjiieHiroshi Shimizu
Jun 7, 2011·Journal of the American Academy of Dermatology·Michael KasperkiewiczEnno Schmidt
Jun 28, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Misa HiroseRalf J Ludwig
Jul 19, 2011·Epilepsia·Florence Canouï-PoitrineElena Paillaud
Sep 20, 2011·Autoimmunity·Annette CzernikSergei A Grando
Sep 20, 2011·Autoimmunity·Michael KasperkiewiczEnno Schmidt
Oct 27, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Andrea Kneisel, Michael Hertl
Nov 8, 2011·Journal of the American Academy of Dermatology·Dedee F MurrellVictoria P Werth
Feb 7, 2012·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Nina van BeekEnno Schmidt
Jul 24, 2012·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Damian MeyersburgDetlef Zillikens
Nov 6, 2012·The British Journal of Dermatology·V A VenningG Kirtschig
Nov 21, 2012·Archives of Dermatology·Vanessa A LondonDavid T Woodley
Dec 15, 2012·Lancet·Enno Schmidt, Detlef Zillikens
Jan 18, 2013·JAMA Dermatology·Antonia Lloyd-LaveryKathy Taghipour

❮ Previous
Next ❯

Citations

Jun 28, 2016·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·F B Löffel, M Stücker
Oct 19, 2017·Praxis·Maja Jenni, Stephan Lautenschlager
Sep 5, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Franziska HübnerEnno Schmidt
Sep 5, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Franziska HübnerEnno Schmidt
May 28, 2015·MMW Fortschritte der Medizin·Claudia ZeidlerSonja Ständer
Dec 7, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Franziska HübnerEnno Schmidt
Oct 31, 2018·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Mareike WitteRalf Ludwig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bullous Pemphigoid

Bullous pemphigoid is a rare immune system disorder and skin condition that causes large, fluid-filled blisters. Bullous pemphigoid commonly affects older adults and appears in areas such as the lower abdomen, upper thighs or armpits. Discover the latest research on bullous pemphigoid here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.