Bumetanide for autism: more eye contact, less amygdala activation

Scientific Reports
Nouchine HadjikhaniYehezkel Ben-Ari

Abstract

We recently showed that constraining eye contact leads to exaggerated increase of amygdala activation in autism. Here, in a proof of concept pilot study, we demonstrate that administration of bumetanide (a NKCC1 chloride importer antagonist that restores GABAergic inhibition) normalizes the level of amygdala activation during constrained eye contact with dynamic emotional face stimuli in autism. In addition, eye-tracking data reveal that bumetanide administration increases the time spent in spontaneous eye gaze during in a free-viewing mode of the same face stimuli. In keeping with clinical trials, our data support the Excitatory/Inhibitory dysfunction hypothesis in autism, and indicate that bumetanide may improve specific aspects of social processing in autism. Future double-blind placebo controlled studies with larger cohorts of participants will help clarify the mechanisms of bumetanide action in autism.

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Clinical Trials Mentioned

NCT01078714

Software Mentioned

Tobii
FILM
FSL Featquery
FLIRT
SPM8
FNIRT
Tobii Studio
FLAME
VBM8
FSL

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