Bumetanide Prevents Brain Trauma-Induced Depressive-Like Behavior

Frontiers in Molecular Neuroscience
Emmanuelle GoubertChristophe Pellegrino

Abstract

Brain trauma triggers a cascade of deleterious events leading to enhanced incidence of drug resistant epilepsies, depression, and cognitive dysfunctions. The underlying mechanisms leading to these alterations are poorly understood and treatment that attenuates those sequels are not available. Using controlled-cortical impact as an experimental model of brain trauma in adult mice, we found a strong suppressive effect of the sodium-potassium-chloride importer (NKCC1) specific antagonist bumetanide on the appearance of depressive-like behavior. We demonstrate that this alteration in behavior is associated with an impairment of post-traumatic secondary neurogenesis within the dentate gyrus of the hippocampus. The mechanism mediating the effect of bumetanide involves early transient changes in the expression of chloride regulatory proteins and qualitative changes in GABA(A) mediated transmission from hyperpolarizing to depolarizing after brain trauma. This work opens new perspectives in the early treatment of human post-traumatic induced depression. Our results strongly suggest that bumetanide might constitute an efficient prophylactic treatment to reduce neurological and psychiatric consequences of brain trauma.

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Citations

Nov 12, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kira A A T LowjagaJoachim Geyer
Apr 4, 2021·International Journal of Molecular Sciences·Nicolas HuguesJérôme Laurin
May 19, 2021·European Journal of Pharmacology·Daiki MatsumotoToshiaki Sendo
May 31, 2021·Seizure : the Journal of the British Epilepsy Association·Cesar E Santana-GomezBrian K Rundle
Dec 4, 2021·Applied Neuropsychology. Child·Zeinab GharaylouMahmoudreza Hadjighassem

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