Bungeanum Improves Cognitive Dysfunction and Neurological Deficits in D-Galactose-Induced Aging Mice via Activating PI3K/Akt/Nrf2 Signaling Pathway

Frontiers in Pharmacology
Meihuan ZhaoShijun Xu

Abstract

Zanthoxylum bungeanum Maxim (Rutaceae), a popular condiment and dietetic herbal medicine, has been used traditionally in the treatment of forgetfulness, as recorded in Shen Nong's Herbal Medicine, an old Chinese medicine book. To explore effects and potential mechanisms of it, extracts of Z. bungeanum through water (WEZ), volatile oil (VOZ), petroleum ether (PEZ), and methylene chloride (MCZ) were used to treat the memory loss induced in D-galactose-induced aging mice. The impaired memory was significantly alleviated after WEZ and VOZ extract treatment. WEZ and VOZ extracts also prevented D-galactose-induced hippocampal neuron damage. In addition, WEZ and VOZ extracts upregulated nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1), which suggests that the effects of WEZ and VOZ extracts on oxidative stress and apoptosis might be involved in the cognitive dysfunctions. Furthermore, WEZ and VOZ extracts enhanced the activation of phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), which suggests that Z. bungeanum has an appreciable therapeutic effect on learning and memory disabilities, and its mechanism may be related to activate PI3K/Akt signaling pathway. Collectively, our study suggested that Z...Continue Reading

References

Oct 3, 2002·Annual Review of Pharmacology and Toxicology·Truyen NguyenCecil B Pickett
Jul 17, 2004·Free Radical Biology & Medicine·Truyen NguyenCecil B Pickett
Jan 6, 2007·Journal of Neuropathology and Experimental Neurology·Chenere P RamseyKelly L Jordan-Sciutto
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Feb 13, 2009·Journal of Agricultural and Food Chemistry·Candice Menozzi-SmarritoFabien Robert
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Katja KanninenJari Koistinaho
Jul 26, 2011·Archives of Gerontology and Geriatrics·Koji TomobeYasuyuki Nomura
May 31, 2014·Journal of Lipid Research·Chuanming LuoHuanxing Su
Aug 12, 2014·International Journal of Biological Macromolecules·Peiqin LiZiling Mao
May 31, 2015·Vascular Pharmacology·Prasanna Abeyrathna, Yunchao Su
Apr 9, 2016·Journal of Basic and Clinical Pharmacy·Anroop B Nair, Shery Jacob
Mar 15, 2018·Journal of Agricultural and Food Chemistry·Jiahuan ChenHuiming Hua
May 4, 2018·Food & Nutrition Research·Huandong ZhaoYuxiang Chen
Oct 20, 2018·Journal of Ethnopharmacology·Wenwen PangXiao-Fang Pei
Dec 30, 2018·International Journal of Biological Macromolecules·Jian LiangShaozhen Hou
Mar 1, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shun DengHai Shen
Mar 20, 2019·Sub-cellular Biochemistry·Sydney M A Juan, Paul A Adlard
Jun 8, 2019·Experimental Gerontology·Gustavo Barja
Oct 28, 2019·The International Journal of Biochemistry & Cell Biology·Jiaxin ZhangLuyang Tao

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Citations

May 21, 2021·Oxidative Medicine and Cellular Longevity·Chao Yu, Jian-Hui Xiao

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Methods Mentioned

BETA
MDA
electrophoresis
nuclear translocation
transgenic

Software Mentioned

EthoVision
ImageJ
Quantity One

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